Metallopanstimulin as a marker for head and neck cancer

Brendan C. Stack, Christopher S. Hollenbeak, Christopher M. Lee, Frank R. Dunphy, Val J. Lowe, Paul D. Hamilton

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. Patients and methods: A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay. Results: HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001). Conclusion: We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients.

Original languageEnglish (US)
Article number45
JournalWorld Journal of Surgical Oncology
Volume2
DOIs
StatePublished - Dec 14 2004

    Fingerprint

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Stack, B. C., Hollenbeak, C. S., Lee, C. M., Dunphy, F. R., Lowe, V. J., & Hamilton, P. D. (2004). Metallopanstimulin as a marker for head and neck cancer. World Journal of Surgical Oncology, 2, [45]. https://doi.org/10.1186/1477-7819-2-45