Metabolism of 1,25-dihydroxyvitamin D3

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Abstract

This review summarizes what is known about the mechanisms by which plasma levels of 1,25-dihydroxyvitamin D3[1,25(OH)2D3], a major calcium-controlling hormone, are regulated. Only a brief review of the regulation of 1,25(OH)2D3 synthesis is given, because this topic has already been reviewed extensively. Instead, the author discusses the mechanisms by which 1,25(OH)2D3 is metabolized to other compounds and the regulation of such metabolic processes. The catabolism of 1,25(OH)2D3 is important because tissue levels of any substance depend on both its rate of formation and its rate of metabolism to other substances.

Original languageEnglish (US)
Pages (from-to)478-504
Number of pages27
JournalPhysiological Reviews
Volume64
Issue number2
StatePublished - 1984

ASJC Scopus subject areas

  • Physiology

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