Metabolic.Clearance and production rates of 3,3′,5′- triiodothyronine in hyperthyroid, euthyroid, and hypothyroid subjects

Robert C. Smallridge, Leonard Wartofsky, Robert E. Desjardins, Kenneth D. Burman

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

To further elucidate the peripheral metabolism of rT3 and to determine if rT3 production rates vary directly with thyroid function, we measured the disappearance of [125I]rT3 in thyrotoxic and hypothyroid subjects as well as in athyreotic patients maintained eumetabolic on exogenous T4. Kinetic parameters were determined by noncompartmental analysis, and serum concentrations of rT3 and T4 were determined by specific RIAs. In six hyperthyroid, seven euthyroid, and six hypothyroid subjects, the MCRs were 190.7 ± 15.7, 111.7 ± 13.2, and 71.8 ± 7.0 liters/day/70 kg, respectively (mean ± SE). Production rates (PR) for these same groups were 271.3 ± 40.5, 51.7 ± 9.1, and 4.3 ± 0.6 μg/day/70 kg. The observed differences in MCR and PR among the three study groups were highly significant (P < 0.002). These data indicate that in comparison to euthyroid subjects, rT3 PR and MCR are increased in thyrotoxic and decreased in hypothyroid individuals.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume47
Issue number2
DOIs
StatePublished - Aug 1978

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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