Abstract
Intracellular metabolic adaptations help define the function and homeostasis of memory CD8+ T cells. These cells, which promote protection against infections or cancer, undergo consecutive metabolic shifts, ultimately relying on mitochondrial-related pathways. Past CD8+ T cell metabolism studies focused on circulating memory cells, which are exclusive to secondary lymphoid organs or recirculate between lymphoid and non-lymphoid organs. Yet, now there is unequivocal evidence that memory CD8+ T cells reside in many non-lymphoid organs and mediate protective immunity in barrier tissues. The metabolic adaptations occurring in forming and established tissue-resident memory CD8+ T cells are currently subject of intense research. In this review, we discuss the latest breakthroughs on the transcriptional and protein control of tissue-resident memory CD8+ T cell metabolism.
Original language | English (US) |
---|---|
Pages (from-to) | 117-124 |
Number of pages | 8 |
Journal | Current Opinion in Pharmacology |
Volume | 57 |
DOIs | |
State | Published - Apr 2021 |
Keywords
- Bhlhe40
- Memory CD8 T cells
- Memory precursor
- Mitochondria
- P2RX7
- T cells
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery