Metabolic regulation of tissue-resident memory CD8+ T cells

Trupti Vardam-Kaur, Jie Sun, Henrique Borges da Silva

Research output: Contribution to journalReview articlepeer-review

Abstract

Intracellular metabolic adaptations help define the function and homeostasis of memory CD8+ T cells. These cells, which promote protection against infections or cancer, undergo consecutive metabolic shifts, ultimately relying on mitochondrial-related pathways. Past CD8+ T cell metabolism studies focused on circulating memory cells, which are exclusive to secondary lymphoid organs or recirculate between lymphoid and non-lymphoid organs. Yet, now there is unequivocal evidence that memory CD8+ T cells reside in many non-lymphoid organs and mediate protective immunity in barrier tissues. The metabolic adaptations occurring in forming and established tissue-resident memory CD8+ T cells are currently subject of intense research. In this review, we discuss the latest breakthroughs on the transcriptional and protein control of tissue-resident memory CD8+ T cell metabolism.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume57
DOIs
StatePublished - Apr 2021

Keywords

  • Bhlhe40
  • Memory CD8 T cells
  • Memory precursor
  • Mitochondria
  • P2RX7
  • T cells

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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