Metabolic plasticity in stem cell homeostasis and differentiation

Clifford D.L. Folmes; Petras P. Dzeja; Timothy J. Nelson; Andre Terzic

doi:10.1016/j.stem.2012.10.002

Metabolic plasticity in stem cell homeostasis and differentiation

Clifford D.L. Folmes, Petras P. Dzeja, Timothy J. Nelson, Andre Terzic

Research output: Contribution to journal › Review article › peer-review

390 Scopus citations

Abstract

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.

Original language	English (US)
Pages (from-to)	596-606
Number of pages	11
Journal	Cell Stem Cell
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2012.10.002
State	Published - Nov 2 2012

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2012.10.002

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title = "Metabolic plasticity in stem cell homeostasis and differentiation",

abstract = "Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.",

author = "Folmes, {Clifford D.L.} and Dzeja, {Petras P.} and Nelson, {Timothy J.} and Andre Terzic",

note = "Funding Information: This work was supported by National Institutes of Health, Canadian Institutes of Health Research, Fondation Leducq, Marriott Foundation, and Mayo Clinic Center for Regenerative Medicine. A.T. holds the Marriott Family Professorship in Cardiovascular Diseases Research at Mayo Clinic.",

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AU - Folmes, Clifford D.L.

AU - Dzeja, Petras P.

AU - Nelson, Timothy J.

AU - Terzic, Andre

N1 - Funding Information: This work was supported by National Institutes of Health, Canadian Institutes of Health Research, Fondation Leducq, Marriott Foundation, and Mayo Clinic Center for Regenerative Medicine. A.T. holds the Marriott Family Professorship in Cardiovascular Diseases Research at Mayo Clinic.

PY - 2012/11/2

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N2 - Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.

AB - Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.

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Metabolic plasticity in stem cell homeostasis and differentiation

Abstract

ASJC Scopus subject areas

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