Metabolic gene variants and risk of non-Hodgkin's lymphoma

Anneclaire J. De Roos, Laura S. Gold, Sophia Wang, Patricia Hartge, James R Cerhan, Wendy Cozen, Meredith Yeager, Stephen Chanock, Nathaniel Rothman, Richard K. Severson

Research output: Contribution to journalArticle

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Abstract

Genes involved in metabolism of environmental chemical exposures exhibit sequence variability that may mediate the risk of non-Hodgkin's lymphoma. We evaluated associations between non-Hodgkin's lymphoma and 15 variants in AHR, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTP1, GSTM3, EPHX1, NQO1, and PON1. Cases were identified from four Surveillance, Epidemiology, and End Results registries in the United States, and population-based controls were identified through random-digit dialing and Medicare eligibility files. Metabolic gene variants were characterized for the 1,172 (89% of total) cases and 982 (93%) controls who provided biological samples for genotyping. Subjects who were heterozygous or homozygous for the cytochrome P450 gene variant CYP1B1 V432L G allele were at slightly greater risk of non-Hodgkin's lymphoma [odds ratio (OR), 1.27; 95% confidence interval (95% CI), 0.97-1.65]; these results were consistent across B-cell lymphoma subtypes and among both non-Hispanic White and Black subjects, although not statistically significant. The CYP2E1 -1054T allele was associated with decreased risk of non-Hodgkin's lymphoma (CT and TT genotypes combined OR, 0.59; 95% CI, 0.37-0.93), and this pattern was observed among all histologic subtypes. The numbers of cases of particular subtypes were rather small for stable estimates, but we noted that the PON1 L55M AA allele, associated with slightly increased risk of non-Hodgkin's lymphoma (variant homozygotes OR, 1.36; 95% CI, 0.96-1.95), was most strongly associated with follicular non-Hodgkin's lymphoma and T-cell lymphoma, with ORs for variant homozygotes of 2.12 and 2.93, respectively. There was no overall association with non-Hodgkin's lymphoma for the other gene variants we examined. The modest effects we observed may reflect the context of exposures within the general population represented in our study.

Original languageEnglish (US)
Pages (from-to)1647-1653
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Non-Hodgkin's Lymphoma
Genes
Cytochrome P-450 CYP2E1
Alleles
Odds Ratio
Homozygote
Confidence Intervals
Cytochrome P-450 CYP1A2
Follicular Lymphoma
Cytochrome P-450 CYP1A1
Population Control
T-Cell Lymphoma
Environmental Exposure
B-Cell Lymphoma
Medicare
Cytochrome P-450 Enzyme System
Registries
Epidemiology
Genotype
Population

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

De Roos, A. J., Gold, L. S., Wang, S., Hartge, P., Cerhan, J. R., Cozen, W., ... Severson, R. K. (2006). Metabolic gene variants and risk of non-Hodgkin's lymphoma. Cancer Epidemiology Biomarkers and Prevention, 15(9), 1647-1653. https://doi.org/10.1158/1055-9965.EPI-06-0193

Metabolic gene variants and risk of non-Hodgkin's lymphoma. / De Roos, Anneclaire J.; Gold, Laura S.; Wang, Sophia; Hartge, Patricia; Cerhan, James R; Cozen, Wendy; Yeager, Meredith; Chanock, Stephen; Rothman, Nathaniel; Severson, Richard K.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 9, 09.2006, p. 1647-1653.

Research output: Contribution to journalArticle

De Roos, AJ, Gold, LS, Wang, S, Hartge, P, Cerhan, JR, Cozen, W, Yeager, M, Chanock, S, Rothman, N & Severson, RK 2006, 'Metabolic gene variants and risk of non-Hodgkin's lymphoma', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 9, pp. 1647-1653. https://doi.org/10.1158/1055-9965.EPI-06-0193
De Roos, Anneclaire J. ; Gold, Laura S. ; Wang, Sophia ; Hartge, Patricia ; Cerhan, James R ; Cozen, Wendy ; Yeager, Meredith ; Chanock, Stephen ; Rothman, Nathaniel ; Severson, Richard K. / Metabolic gene variants and risk of non-Hodgkin's lymphoma. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 9. pp. 1647-1653.
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abstract = "Genes involved in metabolism of environmental chemical exposures exhibit sequence variability that may mediate the risk of non-Hodgkin's lymphoma. We evaluated associations between non-Hodgkin's lymphoma and 15 variants in AHR, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTP1, GSTM3, EPHX1, NQO1, and PON1. Cases were identified from four Surveillance, Epidemiology, and End Results registries in the United States, and population-based controls were identified through random-digit dialing and Medicare eligibility files. Metabolic gene variants were characterized for the 1,172 (89{\%} of total) cases and 982 (93{\%}) controls who provided biological samples for genotyping. Subjects who were heterozygous or homozygous for the cytochrome P450 gene variant CYP1B1 V432L G allele were at slightly greater risk of non-Hodgkin's lymphoma [odds ratio (OR), 1.27; 95{\%} confidence interval (95{\%} CI), 0.97-1.65]; these results were consistent across B-cell lymphoma subtypes and among both non-Hispanic White and Black subjects, although not statistically significant. The CYP2E1 -1054T allele was associated with decreased risk of non-Hodgkin's lymphoma (CT and TT genotypes combined OR, 0.59; 95{\%} CI, 0.37-0.93), and this pattern was observed among all histologic subtypes. The numbers of cases of particular subtypes were rather small for stable estimates, but we noted that the PON1 L55M AA allele, associated with slightly increased risk of non-Hodgkin's lymphoma (variant homozygotes OR, 1.36; 95{\%} CI, 0.96-1.95), was most strongly associated with follicular non-Hodgkin's lymphoma and T-cell lymphoma, with ORs for variant homozygotes of 2.12 and 2.93, respectively. There was no overall association with non-Hodgkin's lymphoma for the other gene variants we examined. The modest effects we observed may reflect the context of exposures within the general population represented in our study.",
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