Koraszülöttek csontanyagcsere-betegsége és genetikai polimorfizmusok

Translated title of the contribution: Metabolic bone disease in premature infants and genetic polymorphisms

Simone Funke, Éva Morava, Márta Czakó, Gabriella Vida, Tibor Ertl, György Kosztolányi

Research output: Contribution to journalArticle

Abstract

Metabolic bone disease is an important complication among infants very-low-birth-weight (< 1500 g). In adults, osteoporosis has been shown to be associated with polymorphisms of vitamin D receptor, estrogen receptor, and collagen Iα1 receptor genes. Aim: The primary goal of the study was to investigate the possible association between metabolic bone disease and the allelic polymorphisms of these three genes. Method: 104 infants very-low-birth-weight were enrolled to the study. Bone formation (serum alkaline phosphatase, osteocalcin) and bone resorption (urinary excretion of calcium and pyridinium crosslink) markers were determined and x-rays of the chest and wrist (together with the distal portions of associated long bones) were obtained. Results: Thirty infants (28,8%) were diagnosed with metabolic bone disease based on high activity of bone formation, bone resorption markers, and positive radiologic signs. Statistically significant correlation between thymine-adenine repeat [(TA)n] allelic variant of estrogen receptor gene and bone disease was observed. Infants with metabolic bone disease more often carried low number of repeats [(TA)n < 19] [odds ratio (OR): 5.82, 95% confidence interval (CI): 2.26-14.98]. Significantly higher number of repeats [(TA)n > 18] was found more frequently in the control group (OR: 0.20, 95% CI: 0.05-0.82). Furthermore significant interaction between vitamin D receptor and collagen Iα1 receptor genotypes (p = 0.023) was observed. In a forward stepwise logistic regression model, bone disorder of preterms correlated with male gender (p = 0.001), duration of hospitalization (p = 0.007), homozygous allelic variants of high number of (TA)n repeats (p = 0.025) and interaction between vitamin D receptor (Tt) and estrogen receptor (homozygous allelic variants of low number of repeats) genotype (p = 0.037). Conclusion: The results suggest that the development of metabolic bone disease in infants very-low-birth-weight may be associated with genetic polymorphisms.

Translated title of the contributionMetabolic bone disease in premature infants and genetic polymorphisms
Original languageHungarian
Pages (from-to)1957-1965
Number of pages9
JournalOrvosi hetilap
Volume148
Issue number41
DOIs
StatePublished - Oct 14 2007

Keywords

  • Clinical risk factors
  • Genetic polymorphisms
  • Metabolic bone disease of premature infants

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Funke, S., Morava, É., Czakó, M., Vida, G., Ertl, T., & Kosztolányi, G. (2007). Koraszülöttek csontanyagcsere-betegsége és genetikai polimorfizmusok. Orvosi hetilap, 148(41), 1957-1965. https://doi.org/10.1556/OH.2007.28179