Metabolic benefits of resistance training and fast glycolytic skeletal muscle

Nathan K. LeBrasseur, Kenneth Walsh, Zoltan Arany

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Skeletal muscle exhibits remarkable plasticity with respect to its metabolic properties. Recent work has shown that interventions such as resistance training, genetic alterations and pharmacological strategies that increase muscle mass and glycolytic capacity, and not necessarily oxidative competence, can improve body composition and systemic metabolism. We review here recent advances in our understanding of the signaling and transcriptional regulatory pathways of this strategy and review new evidence obtained from mice and humans that supports the notion that increasing muscle mass and glycolytic capacity may effectively counter insulin resistance and type 2 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)E3-E10
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume300
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Exercise
  • Insulin resistance
  • Metabolism
  • Myostatin
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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