Metabolic alterations in medication-free patients with bipolar disorder: A 3T CSF-corrected magnetic resonance spectroscopic imaging study

John D Port, Sencan S. Unal, David A. Mrazek, Susan M. Marcus

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The objective of this study was to determine whether cerebrospinal fluid(CSF)-corrected concentrations of N-acetylaspartate are lower in several brain regions of drug- and medication-free subjects with bipolar disorder as compared with matched healthy controls. Bipolar subjects (n = 21) and age- and sex-matched healthy control (n = 21) were studied using proton magnetic resonance spectroscopic imaging on a 3T magnetic resonance (MR) scanner. Spectra were quantified using the LCModel, and metabolite values were CSF-corrected to yield metabolite concentrations. Fourteen regions of interest and five metabolite concentrations in each subject were selected for statistical analysis. We found that bipolar subjects had significantly decreased N-acetylaspartate concentrations in both caudate heads and the left lentiform nucleus. Choline and creatine in the head of the right caudate were also significantly decreased in bipolar subjects. Significantly increased myo-inositol was found in the left caudate head in bipolar subjects. Bipolar subjects showed significantly decreased glutamate/glutamine concentrations in the frontal white matter bilaterally and in the right lentiform nucleus. No differences were found for other metabolites examined. These preliminary findings suggest decreased neuronal density or viability in the basal ganglia and neurometabolic abnormalities in the frontal lobes of subjects with bipolar disorder.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume162
Issue number2
DOIs
StatePublished - Feb 28 2008

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Corpus Striatum
Bipolar Disorder
Cerebrospinal Fluid
Head
Magnetic Resonance Imaging
Creatine
Frontal Lobe
Inositol
Choline
Basal Ganglia
Glutamine
Protons
Glutamic Acid
Magnetic Resonance Spectroscopy
Brain
Pharmaceutical Preparations
N-acetylaspartate
White Matter

Keywords

  • Basal ganglia
  • Creatine
  • Frontal lobe
  • Glutamate/glutamine
  • Myoinositol
  • N-acetylaspartate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Metabolic alterations in medication-free patients with bipolar disorder : A 3T CSF-corrected magnetic resonance spectroscopic imaging study. / Port, John D; Unal, Sencan S.; Mrazek, David A.; Marcus, Susan M.

In: Psychiatry Research - Neuroimaging, Vol. 162, No. 2, 28.02.2008, p. 113-121.

Research output: Contribution to journalArticle

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