Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review

Michele L. Cote; Wei Chen; Daryn W. Smith; Simone Benhamou; Christine Bouchardy; Dorota Butkiewicz; Kwun M. Fong; Manuel Gené; Ari Hirvonen; Chikako Kiyohara; Jill E. Larsen; Pinpin Lin; Ole Raaschou-Nielsen; Andrew C. Povey; Edyta Reszka; Angela Risch; Joachim Schneider; Ann G. Schwartz; Mette Sorensen; Jordi To-Figueras; Shinkan Tokudome; Yuepu Pu; Ping Yang; Angela S. Wenzlaff; Harriet Wikman; Emanuela Taioli

doi:10.1093/aje/kwn417

Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review

Michele L. Cote, Wei Chen, Daryn W. Smith, Simone Benhamou, Christine Bouchardy, Dorota Butkiewicz, Kwun M. Fong, Manuel Gené, Ari Hirvonen, Chikako Kiyohara, Jill E. Larsen, Pinpin Lin, Ole Raaschou-Nielsen, Andrew C. Povey, Edyta Reszka, Angela Risch, Joachim Schneider, Ann G. Schwartz, Mette Sorensen, Jordi To-FiguerasShinkan Tokudome, Yuepu Pu, Ping Yang, Angela S. Wenzlaff, Harriet Wikman, Emanuela Taioli

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.

Original language	English (US)
Pages (from-to)	802-814
Number of pages	13
Journal	American journal of epidemiology
Volume	169
Issue number	7
DOIs	https://doi.org/10.1093/aje/kwn417
State	Published - Apr 2009

Keywords

Asian continental ancestry group
Epidemiology
GSTP1
Glutathione S-transferase pi
Lung neoplasms
Smoking

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/aje/kwn417

Cite this

Cote, M. L., Chen, W., Smith, D. W., Benhamou, S., Bouchardy, C., Butkiewicz, D., Fong, K. M., Gené, M., Hirvonen, A., Kiyohara, C., Larsen, J. E., Lin, P., Raaschou-Nielsen, O., Povey, A. C., Reszka, E., Risch, A., Schneider, J., Schwartz, A. G., Sorensen, M., ... Taioli, E. (2009). Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review. American journal of epidemiology, 169(7), 802-814. https://doi.org/10.1093/aje/kwn417

Cote, ML, Chen, W, Smith, DW, Benhamou, S, Bouchardy, C, Butkiewicz, D, Fong, KM, Gené, M, Hirvonen, A, Kiyohara, C, Larsen, JE, Lin, P, Raaschou-Nielsen, O, Povey, AC, Reszka, E, Risch, A, Schneider, J, Schwartz, AG, Sorensen, M, To-Figueras, J, Tokudome, S, Pu, Y, Yang, P, Wenzlaff, AS, Wikman, H & Taioli, E 2009, 'Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review', American journal of epidemiology, vol. 169, no. 7, pp. 802-814. https://doi.org/10.1093/aje/kwn417

@article{bfc8b5a521fe4537b8c94c3f85685752,

title = "Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review",

abstract = "Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.",

keywords = "Asian continental ancestry group, Epidemiology, GSTP1, Glutathione S-transferase pi, Lung neoplasms, Smoking",

author = "Cote, {Michele L.} and Wei Chen and Smith, {Daryn W.} and Simone Benhamou and Christine Bouchardy and Dorota Butkiewicz and Fong, {Kwun M.} and Manuel Gen{\'e} and Ari Hirvonen and Chikako Kiyohara and Larsen, {Jill E.} and Pinpin Lin and Ole Raaschou-Nielsen and Povey, {Andrew C.} and Edyta Reszka and Angela Risch and Joachim Schneider and Schwartz, {Ann G.} and Mette Sorensen and Jordi To-Figueras and Shinkan Tokudome and Yuepu Pu and Ping Yang and Wenzlaff, {Angela S.} and Harriet Wikman and Emanuela Taioli",

year = "2009",

month = apr,

doi = "10.1093/aje/kwn417",

language = "English (US)",

volume = "169",

pages = "802--814",

journal = "American journal of epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Meta- and pooled analysis of GSTP1 polymorphism and lung cancer

T2 - A HuGE-GSEC review

AU - Cote, Michele L.

AU - Chen, Wei

AU - Smith, Daryn W.

AU - Benhamou, Simone

AU - Bouchardy, Christine

AU - Butkiewicz, Dorota

AU - Fong, Kwun M.

AU - Gené, Manuel

AU - Hirvonen, Ari

AU - Kiyohara, Chikako

AU - Larsen, Jill E.

AU - Lin, Pinpin

AU - Raaschou-Nielsen, Ole

AU - Povey, Andrew C.

AU - Reszka, Edyta

AU - Risch, Angela

AU - Schneider, Joachim

AU - Schwartz, Ann G.

AU - Sorensen, Mette

AU - To-Figueras, Jordi

AU - Tokudome, Shinkan

AU - Pu, Yuepu

AU - Yang, Ping

AU - Wenzlaff, Angela S.

AU - Wikman, Harriet

AU - Taioli, Emanuela

PY - 2009/4

Y1 - 2009/4

N2 - Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.

AB - Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.

KW - Asian continental ancestry group

KW - Epidemiology

KW - GSTP1

KW - Glutathione S-transferase pi

KW - Lung neoplasms

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=63149187299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63149187299&partnerID=8YFLogxK

U2 - 10.1093/aje/kwn417

DO - 10.1093/aje/kwn417

M3 - Review article

C2 - 19240225

AN - SCOPUS:63149187299

SN - 0002-9262

VL - 169

SP - 802

EP - 814

JO - American journal of epidemiology

JF - American journal of epidemiology

IS - 7

ER -

Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this