Meta-analysis of drug-eluting balloon angioplasty and drug-eluting stent placement for infrainguinal peripheral arterial disease

Mark Otto Baerlocher, Sean Alexander Kennedy, Mohammad Reza Rajebi, Felix J. Baerlocher, Sanjay Misra, David Liu, Boris Nikolic

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose To perform a meta-analysis of randomized controlled trials (RCTs) of drug-eluting balloon (DEB) angioplasty and drug-eluting stents (DESs) for infrainguinal peripheral arterial disease. Materials and Methods Systematic searches were performed for all relevant RCTs. Results Eight RCTs for DEB angioplasty and 12 RCTs for a DES in peripheral arterial disease were identified. Meta-analysis demonstrated statistically significant superiority of DEB over plain balloon angioplasty of femoral-popliteal disease for late lumen loss, restenosis, and target lesion revascularization, with no benefit in major amputation or mortality. Statistically significant superiority of DEB over percutaneous transluminal angioplasty (PTA) was demonstrated for infrapopliteal disease for restenosis and target lesion revascularization. Drug-eluting stents showed statistically significant superiority over bare metal stents (BMSs) of femoral-popliteal disease for late lumen loss and restenosis, with no benefit in mortality or amputation. Drug-eluting stents showed statistically significant superiority over BMSs of infrapopliteal disease restenosis and target lesion revascularization, with no benefit in amputation or mortality. Conclusions Drug-eluting balloon angioplasty and DESs demonstrated superior outcomes compared to PTA and BMS, with no difference in amputation or mortality.

Original languageEnglish (US)
Pages (from-to)459-473.e4
JournalJournal of Vascular and Interventional Radiology
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Drug-Eluting Stents
Balloon Angioplasty
Peripheral Arterial Disease
Meta-Analysis
Amputation
Randomized Controlled Trials
Stents
Pharmaceutical Preparations
Mortality
Metals
Thigh
Angioplasty

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Meta-analysis of drug-eluting balloon angioplasty and drug-eluting stent placement for infrainguinal peripheral arterial disease. / Baerlocher, Mark Otto; Kennedy, Sean Alexander; Rajebi, Mohammad Reza; Baerlocher, Felix J.; Misra, Sanjay; Liu, David; Nikolic, Boris.

In: Journal of Vascular and Interventional Radiology, Vol. 26, No. 4, 01.04.2015, p. 459-473.e4.

Research output: Contribution to journalArticle

Baerlocher, Mark Otto ; Kennedy, Sean Alexander ; Rajebi, Mohammad Reza ; Baerlocher, Felix J. ; Misra, Sanjay ; Liu, David ; Nikolic, Boris. / Meta-analysis of drug-eluting balloon angioplasty and drug-eluting stent placement for infrainguinal peripheral arterial disease. In: Journal of Vascular and Interventional Radiology. 2015 ; Vol. 26, No. 4. pp. 459-473.e4.
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