MET: A promising anticancer therapeutic target

Solange Peters, Alex A. Adjei

Research output: Contribution to journalReview article

211 Scopus citations

Abstract

The MET pathway is dysregulated in many human cancers and promotes tumour growth, invasion and dissemination. Abnormalities in MET signalling have been reported to correlate with poor clinical outcomes and drug resistance in patients with cancer. Thus, MET has emerged as an attractive target for cancer therapy. Several MET inhibitors have been introduced into the clinic, and are currently in all phases of clinical trials. In general, initial results from these studies indicate only a modest benefit in unselected populations. In this Review, we discuss current challenges in developing MET inhibitors-including identification of predictive biomarkers-as well as the most-efficient ways to combine these drugs with other targeted agents or with classic chemotherapy or radiotherapy.

Original languageEnglish (US)
Pages (from-to)314-326
Number of pages13
JournalNature Reviews Clinical Oncology
Volume9
Issue number6
DOIs
StatePublished - Jun 1 2012

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ASJC Scopus subject areas

  • Oncology

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