Mesenteric Venous Thrombosis

Bashar Hmoud, Ashwani K. Singal, Patrick S. Kamath

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Mesenteric vein thrombosis is increasingly recognized as a cause of mesenteric ischemia. Acute thrombosis commonly presents with abdominal pain and chronic type with features of portal hypertension. Contrast enhanced CT scan of abdomen is quite accurate for diagnosing and differentiating two types of mesenteric venous thrombosis. Prothrombotic state, hematological malignancy, and local abdominal inflammatory conditions are common predisposing conditions. Over the last decade, JAK-2 (janus kinase 2) mutation has emerged as an accurate biomarker for diagnosis of myeloproliferative neoplasm, an important cause for mesenteric venous thrombosis. Anticoagulation is the treatment of choice for acute mesenteric venous thrombosis. Thrombolysis using systemic or transcatheter route is another option. Patients with peritoneal signs or refractory to initial measures require surgical exploration. Increasing recognition of mesenteric venous thrombosis and use of anticoagulation for treatment has resulted in reduction in the need for surgery with improvement in survival.

Original languageEnglish (US)
Pages (from-to)257-263
Number of pages7
JournalJournal of Clinical and Experimental Hepatology
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2014

Keywords

  • JAK2
  • MVT
  • Mesenteric venous thrombosis
  • PVT
  • Portal hypertension
  • TIPS
  • Thrombosis

ASJC Scopus subject areas

  • Hepatology

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