Mesenteric fibromatosis complicating familial adenomatous polyposis

predisposing factors and results of treatment

A. M. Lotfi, R. R. Dozois, H. Gordon, L. S. Hruska, L. H. Weiland, P. W. Carryer, R. D. Hurt

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Between January 1975 and December 1983, 24 of 183 patients (13%) with familial adenomatous polyposis (FAP) seen at the Mayo Clinic had mesenteric fibromatosis (MF). MF was found most often in FAP patients with associated extra-colonic 'Gardner' signs (19 patients) and those who had had previous abdominal surgery (20 patients). In 4 patients, MF appeared spontaneously. The male-to-female ratio was 0.4, with a median age of 31 years in women and 37 years in men. Ten of 24 patients (42%) had been asymptomatic prior to diagnosis at time of surgery for FAP. Complications of the disease included intestinal or urinary tract obstruction. Minimal surgical manipulation seemed to be associated with fewer postoperative complications and a lesser risk of regrowth of the tumor. Nonsurgical treatment, including tamoxifen and sulindac in combination, may be beneficial. Surgery should be reserved for relief of obstruction, and bypass is preferred to resection.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalInternational Journal of Colorectal Disease
Volume4
Issue number1
StatePublished - 1989

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Adenomatous Polyposis Coli
Fibroma
Causality
Therapeutics
Sulindac
Intestinal Diseases
Tamoxifen
Urinary Tract
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lotfi, A. M., Dozois, R. R., Gordon, H., Hruska, L. S., Weiland, L. H., Carryer, P. W., & Hurt, R. D. (1989). Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and results of treatment. International Journal of Colorectal Disease, 4(1), 30-36.

Mesenteric fibromatosis complicating familial adenomatous polyposis : predisposing factors and results of treatment. / Lotfi, A. M.; Dozois, R. R.; Gordon, H.; Hruska, L. S.; Weiland, L. H.; Carryer, P. W.; Hurt, R. D.

In: International Journal of Colorectal Disease, Vol. 4, No. 1, 1989, p. 30-36.

Research output: Contribution to journalArticle

Lotfi, AM, Dozois, RR, Gordon, H, Hruska, LS, Weiland, LH, Carryer, PW & Hurt, RD 1989, 'Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and results of treatment', International Journal of Colorectal Disease, vol. 4, no. 1, pp. 30-36.
Lotfi, A. M. ; Dozois, R. R. ; Gordon, H. ; Hruska, L. S. ; Weiland, L. H. ; Carryer, P. W. ; Hurt, R. D. / Mesenteric fibromatosis complicating familial adenomatous polyposis : predisposing factors and results of treatment. In: International Journal of Colorectal Disease. 1989 ; Vol. 4, No. 1. pp. 30-36.
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