Mesenchymal stem cells as alternative therapy for brain disorders and their interaction with the immune system

Qian Li; Kaisorn L. Chaichana; Julio J. Rodarte; Alfredo Quiñones-Hinojosa; Hugo Guerrero-Cazares

Mesenchymal stem cells as alternative therapy for brain disorders and their interaction with the immune system

Qian Li, Kaisorn L. Chaichana, Julio J. Rodarte, Alfredo Quiñones-Hinojosa, Hugo Guerrero-Cazares

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Mesenchymal stem cells (MSCs) are cells that have the ability to maintain, self-renew, and give rise to different stromal cell types. These cells can be obtained from a variety of sources that includes bone marrow and adipose tissue. MSCs have an intrinsic tropism towards inflammation and tumor tissues, which makes them an attractive candidate for cellularbased therapies. This chapter summarizes the properties of different sources of MSCs, their potential therapeutic use for brain tumor and other brain disorders, and their interaction with immune system cells. Ultimately, MSCs represent a promising new cellular therapy paradigm where these cells can be used as delivery vehicles for therapeutic molecules or serve as a source of replacement cells in degenerative diseases.

Original language	English (US)
Title of host publication	Neuro-Immune Interactions in the Adult Central Nervous System
Publisher	Nova Science Publishers, Inc.
Pages	87-108
Number of pages	22
ISBN (Electronic)	9781631171291
ISBN (Print)	9781629486468
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Neuroscience

Cite this

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AU - Quiñones-Hinojosa, Alfredo

AU - Guerrero-Cazares, Hugo

PY - 2014/1/1

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AB - Mesenchymal stem cells (MSCs) are cells that have the ability to maintain, self-renew, and give rise to different stromal cell types. These cells can be obtained from a variety of sources that includes bone marrow and adipose tissue. MSCs have an intrinsic tropism towards inflammation and tumor tissues, which makes them an attractive candidate for cellularbased therapies. This chapter summarizes the properties of different sources of MSCs, their potential therapeutic use for brain tumor and other brain disorders, and their interaction with immune system cells. Ultimately, MSCs represent a promising new cellular therapy paradigm where these cells can be used as delivery vehicles for therapeutic molecules or serve as a source of replacement cells in degenerative diseases.

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Mesenchymal stem cells as alternative therapy for brain disorders and their interaction with the immune system

Abstract

ASJC Scopus subject areas

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