Mesenchymal stem cell therapy for inflammatory bowel disease: A systematic review and meta-analysis

Maneesh Dave, Kathan Mehta, Jay Luther, Anushka Baruah, Allan B. Dietz, William A. Faubion

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Recent advances in inflammatory bowel disease (IBD) therapeutics include novel medical, surgical, and endoscopic treatments. Among these, stem cell therapy is still in its infancy, although multiple studies suggest that the immunomodulatory effect of stem cell therapy may reduce inflammation and tissue injury in patients with IBD. This review discusses the novel avenue of stem cell therapy and its potential role in the management of ulcerative colitis and Crohn's disease. We conducted a comprehensive literature search to identify studies examining the role of stem cell therapy (without conditioning and immunomodulatory regimens) in IBD. Taken together, these studies suggest a promising role for stem cell therapy in IBD although the substantial challenges, such as cost and inadequate/incomplete characterization of effect, limit their current use in clinical practice.

Original languageEnglish (US)
Pages (from-to)2696-2707
Number of pages12
JournalInflammatory bowel diseases
Volume21
Issue number11
DOIs
StatePublished - Jul 25 2015

Keywords

  • adverse effects
  • efficacy
  • inflammatory bowel disease
  • mesenchymal stem cells
  • systematic review and meta-analysis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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