Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival

Shane Lloyd, David Baraghoshi, Randa Tao, Ignacio Garrido-Laguna, Glynn W. Gilcrease, Jonathan Whisenant, John R. Weis, Courtney Scaife, Thomas B. Pickron, Lyen C. Huang, Marcus M. Monroe, Sarah Abdelaziz, Alison M. Fraser, Ken R. Smith, Vikrant Deshmukh, Michael Newman, Kerry G. Rowe, John Snyder, Niloy Jewel Samadder, Mia Hashibe

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the risk and risk factors for mental illness among colorectal cancer (CRC) survivors across short-term and long-term follow-up periods. Methods: We used the Utah Cancer Registry to identify CRC survivors diagnosed between 1997 and 2013. Mental health diagnoses were available in electronic medical records and statewide facilities data that were linked by the Utah Population Database. CRC survivors were matched to individuals from a general population cohort. The risk of developing a mental illness was compared between cohorts. The association between mental illness and mortality was also analyzed. Results: In total, 8961 CRC survivors and 35,897 individuals in a general population cohort were identified. CRC survivors were at increased risk for any mental health diagnosis at 0 to 2 years (hazard ratio [HR], 3.70; 95% confidence interval [CI], 3.47-3.95), >2 to 5 years (HR, 1.23; 95% CI, 1.09-1.38), and >5 years (HR, 1.20; 95% CI, 1.07-1.36) after cancer diagnosis. CRC survivors were also at increased risk of depressive disorders specifically during the same time periods. At >5 years, CRC survivors still had an increased risk of developing many mental health diagnoses. Factors associated with increased risk of any mental health disorder among CRC survivors included colostomy and Charlson Comorbidity Index of 1+. There was an increased risk of death for CRC survivors diagnosed with any mental health disorder (HR, 2.18; 95% CI, 2.02-2.35) and depression (HR, 2.10; 95% CI, 1.92-2.28). Conclusions: CRC survivors are at increased risk for mental health disorders in the short-term and long-term. Survivors who develop mental health disorders also experience decreased survival.

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Mental Disorders
Survivors
Colorectal Neoplasms
Mental Health
Survival
Confidence Intervals
Population
Colostomy
Electronic Health Records
Depressive Disorder
Registries
Comorbidity
Neoplasms
Databases
Depression
Mortality

Keywords

  • anxiety
  • colostomy
  • depression
  • Key Words:
  • population health
  • survivorship

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival. / Lloyd, Shane; Baraghoshi, David; Tao, Randa; Garrido-Laguna, Ignacio; Gilcrease, Glynn W.; Whisenant, Jonathan; Weis, John R.; Scaife, Courtney; Pickron, Thomas B.; Huang, Lyen C.; Monroe, Marcus M.; Abdelaziz, Sarah; Fraser, Alison M.; Smith, Ken R.; Deshmukh, Vikrant; Newman, Michael; Rowe, Kerry G.; Snyder, John; Samadder, Niloy Jewel; Hashibe, Mia.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, 01.01.2019.

Research output: Contribution to journalArticle

Lloyd, S, Baraghoshi, D, Tao, R, Garrido-Laguna, I, Gilcrease, GW, Whisenant, J, Weis, JR, Scaife, C, Pickron, TB, Huang, LC, Monroe, MM, Abdelaziz, S, Fraser, AM, Smith, KR, Deshmukh, V, Newman, M, Rowe, KG, Snyder, J, Samadder, NJ & Hashibe, M 2019, 'Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival', American Journal of Clinical Oncology: Cancer Clinical Trials. https://doi.org/10.1097/COC.0000000000000529
Lloyd, Shane ; Baraghoshi, David ; Tao, Randa ; Garrido-Laguna, Ignacio ; Gilcrease, Glynn W. ; Whisenant, Jonathan ; Weis, John R. ; Scaife, Courtney ; Pickron, Thomas B. ; Huang, Lyen C. ; Monroe, Marcus M. ; Abdelaziz, Sarah ; Fraser, Alison M. ; Smith, Ken R. ; Deshmukh, Vikrant ; Newman, Michael ; Rowe, Kerry G. ; Snyder, John ; Samadder, Niloy Jewel ; Hashibe, Mia. / Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2019.
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title = "Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival",
abstract = "Objectives: To determine the risk and risk factors for mental illness among colorectal cancer (CRC) survivors across short-term and long-term follow-up periods. Methods: We used the Utah Cancer Registry to identify CRC survivors diagnosed between 1997 and 2013. Mental health diagnoses were available in electronic medical records and statewide facilities data that were linked by the Utah Population Database. CRC survivors were matched to individuals from a general population cohort. The risk of developing a mental illness was compared between cohorts. The association between mental illness and mortality was also analyzed. Results: In total, 8961 CRC survivors and 35,897 individuals in a general population cohort were identified. CRC survivors were at increased risk for any mental health diagnosis at 0 to 2 years (hazard ratio [HR], 3.70; 95{\%} confidence interval [CI], 3.47-3.95), >2 to 5 years (HR, 1.23; 95{\%} CI, 1.09-1.38), and >5 years (HR, 1.20; 95{\%} CI, 1.07-1.36) after cancer diagnosis. CRC survivors were also at increased risk of depressive disorders specifically during the same time periods. At >5 years, CRC survivors still had an increased risk of developing many mental health diagnoses. Factors associated with increased risk of any mental health disorder among CRC survivors included colostomy and Charlson Comorbidity Index of 1+. There was an increased risk of death for CRC survivors diagnosed with any mental health disorder (HR, 2.18; 95{\%} CI, 2.02-2.35) and depression (HR, 2.10; 95{\%} CI, 1.92-2.28). Conclusions: CRC survivors are at increased risk for mental health disorders in the short-term and long-term. Survivors who develop mental health disorders also experience decreased survival.",
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author = "Shane Lloyd and David Baraghoshi and Randa Tao and Ignacio Garrido-Laguna and Gilcrease, {Glynn W.} and Jonathan Whisenant and Weis, {John R.} and Courtney Scaife and Pickron, {Thomas B.} and Huang, {Lyen C.} and Monroe, {Marcus M.} and Sarah Abdelaziz and Fraser, {Alison M.} and Smith, {Ken R.} and Vikrant Deshmukh and Michael Newman and Rowe, {Kerry G.} and John Snyder and Samadder, {Niloy Jewel} and Mia Hashibe",
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T1 - Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated with Decreased Overall Survival

AU - Lloyd, Shane

AU - Baraghoshi, David

AU - Tao, Randa

AU - Garrido-Laguna, Ignacio

AU - Gilcrease, Glynn W.

AU - Whisenant, Jonathan

AU - Weis, John R.

AU - Scaife, Courtney

AU - Pickron, Thomas B.

AU - Huang, Lyen C.

AU - Monroe, Marcus M.

AU - Abdelaziz, Sarah

AU - Fraser, Alison M.

AU - Smith, Ken R.

AU - Deshmukh, Vikrant

AU - Newman, Michael

AU - Rowe, Kerry G.

AU - Snyder, John

AU - Samadder, Niloy Jewel

AU - Hashibe, Mia

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To determine the risk and risk factors for mental illness among colorectal cancer (CRC) survivors across short-term and long-term follow-up periods. Methods: We used the Utah Cancer Registry to identify CRC survivors diagnosed between 1997 and 2013. Mental health diagnoses were available in electronic medical records and statewide facilities data that were linked by the Utah Population Database. CRC survivors were matched to individuals from a general population cohort. The risk of developing a mental illness was compared between cohorts. The association between mental illness and mortality was also analyzed. Results: In total, 8961 CRC survivors and 35,897 individuals in a general population cohort were identified. CRC survivors were at increased risk for any mental health diagnosis at 0 to 2 years (hazard ratio [HR], 3.70; 95% confidence interval [CI], 3.47-3.95), >2 to 5 years (HR, 1.23; 95% CI, 1.09-1.38), and >5 years (HR, 1.20; 95% CI, 1.07-1.36) after cancer diagnosis. CRC survivors were also at increased risk of depressive disorders specifically during the same time periods. At >5 years, CRC survivors still had an increased risk of developing many mental health diagnoses. Factors associated with increased risk of any mental health disorder among CRC survivors included colostomy and Charlson Comorbidity Index of 1+. There was an increased risk of death for CRC survivors diagnosed with any mental health disorder (HR, 2.18; 95% CI, 2.02-2.35) and depression (HR, 2.10; 95% CI, 1.92-2.28). Conclusions: CRC survivors are at increased risk for mental health disorders in the short-term and long-term. Survivors who develop mental health disorders also experience decreased survival.

AB - Objectives: To determine the risk and risk factors for mental illness among colorectal cancer (CRC) survivors across short-term and long-term follow-up periods. Methods: We used the Utah Cancer Registry to identify CRC survivors diagnosed between 1997 and 2013. Mental health diagnoses were available in electronic medical records and statewide facilities data that were linked by the Utah Population Database. CRC survivors were matched to individuals from a general population cohort. The risk of developing a mental illness was compared between cohorts. The association between mental illness and mortality was also analyzed. Results: In total, 8961 CRC survivors and 35,897 individuals in a general population cohort were identified. CRC survivors were at increased risk for any mental health diagnosis at 0 to 2 years (hazard ratio [HR], 3.70; 95% confidence interval [CI], 3.47-3.95), >2 to 5 years (HR, 1.23; 95% CI, 1.09-1.38), and >5 years (HR, 1.20; 95% CI, 1.07-1.36) after cancer diagnosis. CRC survivors were also at increased risk of depressive disorders specifically during the same time periods. At >5 years, CRC survivors still had an increased risk of developing many mental health diagnoses. Factors associated with increased risk of any mental health disorder among CRC survivors included colostomy and Charlson Comorbidity Index of 1+. There was an increased risk of death for CRC survivors diagnosed with any mental health disorder (HR, 2.18; 95% CI, 2.02-2.35) and depression (HR, 2.10; 95% CI, 1.92-2.28). Conclusions: CRC survivors are at increased risk for mental health disorders in the short-term and long-term. Survivors who develop mental health disorders also experience decreased survival.

KW - anxiety

KW - colostomy

KW - depression

KW - Key Words:

KW - population health

KW - survivorship

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