TY - JOUR
T1 - Menstrual blood transplantation for ischemic stroke
T2 - Therapeutic mechanisms and practical issues
AU - Rodrigues, Maria Carolina O.
AU - Dmitriev, Dmitriy
AU - Rodrigues, Antonio
AU - Glover, Loren E.
AU - Sanberg, Paul R.
AU - Allickson, Julie G.
AU - Kuzmin-Nichols, Nicole
AU - Tajiri, Naoki
AU - Shinozuka, Kazutaka
AU - Garbuzova-Davis, Svitlana
AU - Kaneko, Yuji
AU - Borlongan, Cesar V.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Cerebrovascular diseases are a major cause of death and long-term disability in developed countries. Tissue plasmin activator (tPA) is the only approved therapy for ischemic stroke, strongly limited by the short therapeutic window and hemorrhagic complications, therefore excluding most patients from its benefits. The rescue of the penumbra area of the ischemic infarct is decisive for functional recovery after stroke. Inflammation is a key feature in the penumbra area and it plays a dual role, improving injury in early phases but impairing neural survival at later stages. Stem cells can be opportunely used to modulate inflammation, abrogate cell death and, therefore, preserve neural function. We here discuss the possible role of stem cells derived from menstrual blood as restorative treatment for stroke. We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications.
AB - Cerebrovascular diseases are a major cause of death and long-term disability in developed countries. Tissue plasmin activator (tPA) is the only approved therapy for ischemic stroke, strongly limited by the short therapeutic window and hemorrhagic complications, therefore excluding most patients from its benefits. The rescue of the penumbra area of the ischemic infarct is decisive for functional recovery after stroke. Inflammation is a key feature in the penumbra area and it plays a dual role, improving injury in early phases but impairing neural survival at later stages. Stem cells can be opportunely used to modulate inflammation, abrogate cell death and, therefore, preserve neural function. We here discuss the possible role of stem cells derived from menstrual blood as restorative treatment for stroke. We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications.
KW - cell-based therapy
KW - endometrium-derived stem cells
KW - menstrual blood stem cells
KW - penumbra area
KW - restorative treatment
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84865259912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865259912&partnerID=8YFLogxK
U2 - 10.1556/IMAS.4.2012.2.1
DO - 10.1556/IMAS.4.2012.2.1
M3 - Review article
AN - SCOPUS:84865259912
SN - 2061-1617
VL - 4
SP - 59
EP - 68
JO - Interventional Medicine and Applied Science
JF - Interventional Medicine and Applied Science
IS - 2
ER -