Menstrual and reproductive factors and risk of non-Hodgkin lymphoma: The Iowa Women's Health Study (United States)

James R Cerhan, Thomas Matthew Habermann, Celine M Vachon, Shannon D. Putnam, Wei Zheng, John D. Potter, Aaron R. Folsom

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Endogenous sex hormones, particularly estrogens, modulate the immune system, and non-Hodgkin lymphoma (NHL) is a tumor that is related to immunologic status. Methods: Self-reported menstrual and reproductive history and risk of NHL were evaluated in a cohort of 37,934 Iowa women who were aged 55-69 years when first enrolled in 1986. Through 1998, 261 cases of NHL were identified by linkage to the Iowa SEER Cancer Registry. Results: After multivariate adjustment there was no association between NHL incidence and age at menarche, age at menopause, type of menopause, history of infertility, number of miscarriages, or history of induced abortion, while there were suggestive inverse associations with nulliparity (RR=0.65; 95% CI 0.36-1.16) and years of ovulation (RR = 0.76 for ≥37 compared to <28 ovulatory years; p-trend = 0.07). Among parous women there was no association with number of livebirths or age at first livebirth, but there was an inverse association with number of children who were breast-fed (RR=0.52 for breast-feeding >2 children versus none; 95% CI 0.33-0.82). Conclusions: Overall, menstrual and reproductive factors were not strongly related to NHL incidence. The inverse association with breast-feeding is novel but requires confirmation in other studies.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalCancer Causes and Control
Volume13
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Women's Health
Non-Hodgkin's Lymphoma
Menopause
Social Adjustment
Reproductive History
Menarche
Induced Abortion
Incidence
Gonadal Steroid Hormones
Spontaneous Abortion
Ovulation
Parity
Breast Feeding
Infertility
Registries
Immune System
Neoplasms
Estrogens

Keywords

  • Breast-feeding
  • Cohort studies
  • Non-Hodgkin lymphoma
  • Reproductive factors

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Menstrual and reproductive factors and risk of non-Hodgkin lymphoma : The Iowa Women's Health Study (United States). / Cerhan, James R; Habermann, Thomas Matthew; Vachon, Celine M; Putnam, Shannon D.; Zheng, Wei; Potter, John D.; Folsom, Aaron R.

In: Cancer Causes and Control, Vol. 13, No. 2, 2002, p. 131-136.

Research output: Contribution to journalArticle

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