@article{32470e9f0e644649b884b4a227a9e52c,
title = "Menstrual and reproductive factors, and hormonal contraception use: Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies",
abstract = "Background: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. Materials and methods: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. Results: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR. trend = 0.88, 95% CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for <5 years or stopped for >20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95% CI 0.65-1.16). Conclusions: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.",
keywords = "Case-control studies, Diffuse large B-cell lymphoma, Follicular lymphoma, Hormonal contraceptives, Non-Hodgkin lymphoma, Reproductive history",
author = "Kane, {E. V.} and E. Roman and N. Becker and L. Bernstein and P. Boffetta and Bracci, {P. M.} and Cerhan, {J. R.} and Chiu, {B. C.H.} and P. Cocco and L. Costas and L. Foretova and Holly, {E. A.} and {La vecchia}, C. and K. Matsuo and M. Maynadie and S. Sanjose and Spinelli, {J. J.} and A. Staines and R. Talamini and Wang, {S. S.} and Y. Zhang and T. Zheng and A. Kricker",
note = "Funding Information: This work was supported by the National Cancer Institute (grants PC65064, PC67008, PC67009, PC67010 and PC71105 to the NCI-SEER study); National Cancer Institute (grant CA62006 to the Connecticut study); American Institute for Cancer Research (grant 99B083 to the Nebraska study); National Cancer Institute (grants CA92153 and CA97274 to the Mayo study); National Institute of Health (grants CA45614, CA89745, CA87014, CA150037 and CA143947 to the UCSF study); National Cancer Institute (grant CA50850 to the Los Angeles study); the Canadian Cancer Society through the National Cancer Institute of Canada, the Canadian Institutes for Health Research, and the Chan Sisters Foundation (the British Columbia study); the Leukaemia and Lymphoma Research (the UK study); European Commission (grant QLK4-CT-2000–00422 to the EpiLymph study); Association pour la Recherche contre le Cancer and Fondation de France (grants 5111 and 1999 008471 to the EpiLymph-France study); Compagnia di San Paolo di Torino, Programma Oncologia 2001 (the EpiLymph-Italy study); Health Research Board (the EpiLymph-Ireland study); Spanish Ministry of Health (FISS grant PI040091, PI081555, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095 and CIBERESP 06/ 06/0073) and Marato de TV3 Foundation (grant 051210 to the EpiLymph-Spain study); German Federal Office for Radiation Protection (grants StSch4261 and StSch4420 to the EpiLymph-Germany study); the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101 to EpiLymph-Czech Republic study); the National Research Council (CNR) Applied Project {\textquoteleft}Clinical Applications of Oncological Research{\textquoteright} and the Italian Association for Cancer Research (the Northern Italy study); the European Community (Europe Against Cancer Programme), the Lega Italiana per la Lotta Contro i Tumori and Italian Association for Research on Cancer (the Italy study); and Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan (HERPACC1 and 2 studies).",
year = "2012",
month = sep,
doi = "10.1093/annonc/mds171",
language = "English (US)",
volume = "23",
pages = "2362--2374",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "9",
}