Menstrual and reproductive factors, and hormonal contraception use: Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies

E. V. Kane, E. Roman, N. Becker, L. Bernstein, P. Boffetta, P. M. Bracci, James R Cerhan, B. C H Chiu, P. Cocco, L. Costas, L. Foretova, E. A. Holly, C. La vecchia, K. Matsuo, M. Maynadie, S. Sanjose, J. J. Spinelli, A. Staines, R. Talamini, S. S. WangY. Zhang, T. Zheng, A. Kricker

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. Materials and methods: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. Results: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR. trend = 0.88, 95% CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for <5 years or stopped for >20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95% CI 0.65-1.16). Conclusions: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.

Original languageEnglish (US)
Article numbermds171
Pages (from-to)2362-2374
Number of pages13
JournalAnnals of Oncology
Volume23
Issue number9
DOIs
StatePublished - Sep 2012

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Follicular Lymphoma
Contraception
Non-Hodgkin's Lymphoma
Lymphoma, Large B-Cell, Diffuse
Case-Control Studies
Odds Ratio
Confidence Intervals
Reproductive History
Sex Ratio
North America
Meta-Analysis
Japan
Logistic Models
Pregnancy
Neoplasms

Keywords

  • Case-control studies
  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Hormonal contraceptives
  • Non-Hodgkin lymphoma
  • Reproductive history

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Menstrual and reproductive factors, and hormonal contraception use : Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies. / Kane, E. V.; Roman, E.; Becker, N.; Bernstein, L.; Boffetta, P.; Bracci, P. M.; Cerhan, James R; Chiu, B. C H; Cocco, P.; Costas, L.; Foretova, L.; Holly, E. A.; La vecchia, C.; Matsuo, K.; Maynadie, M.; Sanjose, S.; Spinelli, J. J.; Staines, A.; Talamini, R.; Wang, S. S.; Zhang, Y.; Zheng, T.; Kricker, A.

In: Annals of Oncology, Vol. 23, No. 9, mds171, 09.2012, p. 2362-2374.

Research output: Contribution to journalArticle

Kane, EV, Roman, E, Becker, N, Bernstein, L, Boffetta, P, Bracci, PM, Cerhan, JR, Chiu, BCH, Cocco, P, Costas, L, Foretova, L, Holly, EA, La vecchia, C, Matsuo, K, Maynadie, M, Sanjose, S, Spinelli, JJ, Staines, A, Talamini, R, Wang, SS, Zhang, Y, Zheng, T & Kricker, A 2012, 'Menstrual and reproductive factors, and hormonal contraception use: Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies', Annals of Oncology, vol. 23, no. 9, mds171, pp. 2362-2374. https://doi.org/10.1093/annonc/mds171
Kane, E. V. ; Roman, E. ; Becker, N. ; Bernstein, L. ; Boffetta, P. ; Bracci, P. M. ; Cerhan, James R ; Chiu, B. C H ; Cocco, P. ; Costas, L. ; Foretova, L. ; Holly, E. A. ; La vecchia, C. ; Matsuo, K. ; Maynadie, M. ; Sanjose, S. ; Spinelli, J. J. ; Staines, A. ; Talamini, R. ; Wang, S. S. ; Zhang, Y. ; Zheng, T. ; Kricker, A. / Menstrual and reproductive factors, and hormonal contraception use : Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies. In: Annals of Oncology. 2012 ; Vol. 23, No. 9. pp. 2362-2374.
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abstract = "Background: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. Materials and methods: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. Results: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR. trend = 0.88, 95{\%} CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95{\%} CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for <5 years or stopped for >20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95{\%} CI 0.65-1.16). Conclusions: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.",
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T2 - Associations with non-hodgkin lymphoma in a pooled analysis of interlymph case-control studies

AU - Kane, E. V.

AU - Roman, E.

AU - Becker, N.

AU - Bernstein, L.

AU - Boffetta, P.

AU - Bracci, P. M.

AU - Cerhan, James R

AU - Chiu, B. C H

AU - Cocco, P.

AU - Costas, L.

AU - Foretova, L.

AU - Holly, E. A.

AU - La vecchia, C.

AU - Matsuo, K.

AU - Maynadie, M.

AU - Sanjose, S.

AU - Spinelli, J. J.

AU - Staines, A.

AU - Talamini, R.

AU - Wang, S. S.

AU - Zhang, Y.

AU - Zheng, T.

AU - Kricker, A.

PY - 2012/9

Y1 - 2012/9

N2 - Background: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. Materials and methods: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. Results: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR. trend = 0.88, 95% CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for <5 years or stopped for >20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95% CI 0.65-1.16). Conclusions: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.

AB - Background: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. Materials and methods: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. Results: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR. trend = 0.88, 95% CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for <5 years or stopped for >20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95% CI 0.65-1.16). Conclusions: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.

KW - Case-control studies

KW - Diffuse large B-cell lymphoma

KW - Follicular lymphoma

KW - Hormonal contraceptives

KW - Non-Hodgkin lymphoma

KW - Reproductive history

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