Menopause and Menopausal Hormone Therapy in Women: Cardiovascular Benefits and Risks

Anna Svatikova, Sharonne N. Hayes

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The last decade has brought many challenges and uncertainties regarding the use of menopausal hormone therapy in women. Two early key studies, the Heart and Estrogen/Progestin Replacement Study (HERS) and the Women's Health Initiative (WHI) failed to prove beneficial effects of exogenous estrogen, and estrogen combined with progestin, in cardiovascular prevention. More recent studies, however, introduced the concept of a possible "window-of-opportunity" for hormonal therapy, in which menopausal hormone therapy is used early after the onset of menopause, and may lead to more favorable, cardio-protective outcomes. Despite the increasing wealth of clinical data, menopausal hormone therapy is not currently recommended for primary or secondary prevention of coronary heart disease in women. Further research is needed to understand the risk-benefit balance of menopausal hormone therapy.

Original languageEnglish (US)
JournalRevista Colombiana de Cardiologia
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Cardiovascular prevention
  • Menopausal hormone therapy
  • Menopause
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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