Memory function in very early Alzheimer's disease

Ronald Carl Petersen, G. E. Smith, R. J. Ivnik, E. Kokmen, Eric George Tangalos

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

The detection of very early Alzheimer's disease (AD) can be important for both theoretical and practical reasons. Typically, a memory impairment is the first sign of incipient disease, but the early clinical diagnosis can be challenging. We investigated several aspects of memory function in AD and normal aging to determine which indices of performance were most sensitive at detecting early impairments. We evaluated 106 pairs of patients with probable AD and matched controls from the Mayo Clinic Alzheimer's Disease Patient Registry using a logistic regression model that included measures of memory function, verbal and nonverbal intelligence, attention, and language. Results indicated that an index of learning, especially with semantic cuing, was most sensitive at separating the two groups. We then matched subsets of individuals from the larger groups of AD and control subjects on the Mini- Mental State Examination (range of scores, 24 to 26). A logistic regression analysis on these matched groups yielded the same results. A measure of learning with facilitation of performance using cues appears to be the best discrimination at detecting very mild AD. These measures can be useful in selecting patients for interventional strategies.

Original languageEnglish (US)
Pages (from-to)867-872
Number of pages6
JournalNeurology
Volume44
Issue number5
StatePublished - May 1994

Fingerprint

Alzheimer Disease
Logistic Models
Learning
Intelligence
Semantics
Cues
Registries
Early Diagnosis
Research Design
Language
Regression Analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Petersen, R. C., Smith, G. E., Ivnik, R. J., Kokmen, E., & Tangalos, E. G. (1994). Memory function in very early Alzheimer's disease. Neurology, 44(5), 867-872.

Memory function in very early Alzheimer's disease. / Petersen, Ronald Carl; Smith, G. E.; Ivnik, R. J.; Kokmen, E.; Tangalos, Eric George.

In: Neurology, Vol. 44, No. 5, 05.1994, p. 867-872.

Research output: Contribution to journalArticle

Petersen, RC, Smith, GE, Ivnik, RJ, Kokmen, E & Tangalos, EG 1994, 'Memory function in very early Alzheimer's disease', Neurology, vol. 44, no. 5, pp. 867-872.
Petersen RC, Smith GE, Ivnik RJ, Kokmen E, Tangalos EG. Memory function in very early Alzheimer's disease. Neurology. 1994 May;44(5):867-872.
Petersen, Ronald Carl ; Smith, G. E. ; Ivnik, R. J. ; Kokmen, E. ; Tangalos, Eric George. / Memory function in very early Alzheimer's disease. In: Neurology. 1994 ; Vol. 44, No. 5. pp. 867-872.
@article{93834966b8da4b11be45c866b204087c,
title = "Memory function in very early Alzheimer's disease",
abstract = "The detection of very early Alzheimer's disease (AD) can be important for both theoretical and practical reasons. Typically, a memory impairment is the first sign of incipient disease, but the early clinical diagnosis can be challenging. We investigated several aspects of memory function in AD and normal aging to determine which indices of performance were most sensitive at detecting early impairments. We evaluated 106 pairs of patients with probable AD and matched controls from the Mayo Clinic Alzheimer's Disease Patient Registry using a logistic regression model that included measures of memory function, verbal and nonverbal intelligence, attention, and language. Results indicated that an index of learning, especially with semantic cuing, was most sensitive at separating the two groups. We then matched subsets of individuals from the larger groups of AD and control subjects on the Mini- Mental State Examination (range of scores, 24 to 26). A logistic regression analysis on these matched groups yielded the same results. A measure of learning with facilitation of performance using cues appears to be the best discrimination at detecting very mild AD. These measures can be useful in selecting patients for interventional strategies.",
author = "Petersen, {Ronald Carl} and Smith, {G. E.} and Ivnik, {R. J.} and E. Kokmen and Tangalos, {Eric George}",
year = "1994",
month = "5",
language = "English (US)",
volume = "44",
pages = "867--872",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Memory function in very early Alzheimer's disease

AU - Petersen, Ronald Carl

AU - Smith, G. E.

AU - Ivnik, R. J.

AU - Kokmen, E.

AU - Tangalos, Eric George

PY - 1994/5

Y1 - 1994/5

N2 - The detection of very early Alzheimer's disease (AD) can be important for both theoretical and practical reasons. Typically, a memory impairment is the first sign of incipient disease, but the early clinical diagnosis can be challenging. We investigated several aspects of memory function in AD and normal aging to determine which indices of performance were most sensitive at detecting early impairments. We evaluated 106 pairs of patients with probable AD and matched controls from the Mayo Clinic Alzheimer's Disease Patient Registry using a logistic regression model that included measures of memory function, verbal and nonverbal intelligence, attention, and language. Results indicated that an index of learning, especially with semantic cuing, was most sensitive at separating the two groups. We then matched subsets of individuals from the larger groups of AD and control subjects on the Mini- Mental State Examination (range of scores, 24 to 26). A logistic regression analysis on these matched groups yielded the same results. A measure of learning with facilitation of performance using cues appears to be the best discrimination at detecting very mild AD. These measures can be useful in selecting patients for interventional strategies.

AB - The detection of very early Alzheimer's disease (AD) can be important for both theoretical and practical reasons. Typically, a memory impairment is the first sign of incipient disease, but the early clinical diagnosis can be challenging. We investigated several aspects of memory function in AD and normal aging to determine which indices of performance were most sensitive at detecting early impairments. We evaluated 106 pairs of patients with probable AD and matched controls from the Mayo Clinic Alzheimer's Disease Patient Registry using a logistic regression model that included measures of memory function, verbal and nonverbal intelligence, attention, and language. Results indicated that an index of learning, especially with semantic cuing, was most sensitive at separating the two groups. We then matched subsets of individuals from the larger groups of AD and control subjects on the Mini- Mental State Examination (range of scores, 24 to 26). A logistic regression analysis on these matched groups yielded the same results. A measure of learning with facilitation of performance using cues appears to be the best discrimination at detecting very mild AD. These measures can be useful in selecting patients for interventional strategies.

UR - http://www.scopus.com/inward/record.url?scp=0028305117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028305117&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 867

EP - 872

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -