Membrane protein targeting to the MVB/lysosome

Brian A. Davies; Jacqueline R.E. Lee; Andrea J. Oestreich; David J. Katzmann

doi:10.1021/cr800473s

Membrane protein targeting to the MVB/lysosome

Brian A. Davies, Jacqueline R.E. Lee, Andrea J. Oestreich, David J. Katzmann

Biochemistry and Molecular Biology

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

A study was conducted to examine the effect of multivesicular body (MVB) sorting on membrane protein function. MVB sorting reaction within the endocytic pathway showed a cellular mechanism for terminating the function of integral membrane proteins destined for degradation within the lysosome. It was found that MVB sorting recognized a subset of endocytic cargoes and concentrated them into regions within the endosomal membrane. Fusion of the MVB with the lysosome delivered intralumenal vesicles to the hydrolytic environment of the lysosome, where the lipid and protein contents of the vesicles were degraded. The topology of membrane invagination into the endosomal lumen during MVB sorting was found similar to the budding process. The MVB sorting can be used for viral replication and for lysosomal delivery of endocytosed proteins.

Original language	English (US)
Pages (from-to)	1575-1586
Number of pages	12
Journal	Chemical reviews
Volume	109
Issue number	4
DOIs	https://doi.org/10.1021/cr800473s
State	Published - Apr 8 2009

ASJC Scopus subject areas

Chemistry(all)

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title = "Membrane protein targeting to the MVB/lysosome",

abstract = "A study was conducted to examine the effect of multivesicular body (MVB) sorting on membrane protein function. MVB sorting reaction within the endocytic pathway showed a cellular mechanism for terminating the function of integral membrane proteins destined for degradation within the lysosome. It was found that MVB sorting recognized a subset of endocytic cargoes and concentrated them into regions within the endosomal membrane. Fusion of the MVB with the lysosome delivered intralumenal vesicles to the hydrolytic environment of the lysosome, where the lipid and protein contents of the vesicles were degraded. The topology of membrane invagination into the endosomal lumen during MVB sorting was found similar to the budding process. The MVB sorting can be used for viral replication and for lysosomal delivery of endocytosed proteins.",

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AU - Davies, Brian A.

AU - Lee, Jacqueline R.E.

AU - Oestreich, Andrea J.

AU - Katzmann, David J.

PY - 2009/4/8

Y1 - 2009/4/8

N2 - A study was conducted to examine the effect of multivesicular body (MVB) sorting on membrane protein function. MVB sorting reaction within the endocytic pathway showed a cellular mechanism for terminating the function of integral membrane proteins destined for degradation within the lysosome. It was found that MVB sorting recognized a subset of endocytic cargoes and concentrated them into regions within the endosomal membrane. Fusion of the MVB with the lysosome delivered intralumenal vesicles to the hydrolytic environment of the lysosome, where the lipid and protein contents of the vesicles were degraded. The topology of membrane invagination into the endosomal lumen during MVB sorting was found similar to the budding process. The MVB sorting can be used for viral replication and for lysosomal delivery of endocytosed proteins.

AB - A study was conducted to examine the effect of multivesicular body (MVB) sorting on membrane protein function. MVB sorting reaction within the endocytic pathway showed a cellular mechanism for terminating the function of integral membrane proteins destined for degradation within the lysosome. It was found that MVB sorting recognized a subset of endocytic cargoes and concentrated them into regions within the endosomal membrane. Fusion of the MVB with the lysosome delivered intralumenal vesicles to the hydrolytic environment of the lysosome, where the lipid and protein contents of the vesicles were degraded. The topology of membrane invagination into the endosomal lumen during MVB sorting was found similar to the budding process. The MVB sorting can be used for viral replication and for lysosomal delivery of endocytosed proteins.

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Membrane protein targeting to the MVB/lysosome

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