@article{ad0a524406134809aaa08fc938b4a118,
title = "Melatonin therapy for REM sleep behavior disorder: A critical review of evidence",
abstract = "Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with dream enactment often involving violent or potentially injurious behaviors during REM sleep that is strongly associated with synucleinopathy neurodegeneration. Clonazepam has long been suggested as the first-line treatment option for RBD. However, evidence supporting melatonin therapy is expanding. Melatonin appears to be beneficial for the management of RBD with reductions in clinical behavioral outcomes and decrease in muscle tonicity during REM sleep. Melatonin also has a favorable safety and tolerability profile over clonazepam with limited potential for drug-drug interactions, an important consideration especially in elderly individuals with RBD receiving polypharmacy. Prospective clinical trials are necessary to establish the evidence basis for melatonin and clonazepam as RBD therapies.",
keywords = "Calmodulin, Drug therapy, Melatonin, Parasomnia, REM sleep behavior disorder",
author = "McGrane, {Ian R.} and Leung, {Jonathan G.} and {St. Louis}, {Erik K.} and Boeve, {Bradley F.}",
note = "Funding Information: EK St. Louis reports that he receives research support from the Mayo Clinic Center for Translational Science Activities (CTSA), supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences , National Institutes of Health , through Grant Number 1 UL1 RR024150-01 . Funding Information: BF Boeve reports that he is an investigator in clinical trials sponsored by Cephalon, Inc., Allon Pharmaceuticals, and GE Healthcare. He receives royalties from the publication of a book entitled Behavioral Neurology of Dementia (CambridgeMedicine, 2009). He has received honoraria from the American Academy of Neurology. He serves on the Scientific Advisory Board of the Tau Consortium. He receives research support from the National Institute on Aging (P50 AG016574 , U01 AG006786 , RO1 AG032306 , RO1 AG041797 ) and the Mangurian Foundation. Funding Information: The project described was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health (NIH), through Grant Number 1 UL1 RR024150-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. ",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.sleep.2014.09.011",
language = "English (US)",
volume = "16",
pages = "19--26",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier",
number = "1",
}