Melanoma-induced brain metastases

Robert R Mc Williams, Ravi D. Rao, Jan Craig Buckner, Michael J. Link, Svetomir Nenad Markovic, Paul D. Brown

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Brain metastases are a common site of metastasis from malignant melanoma, and are associated with a poor prognosis. Diagnosis of brain metastasis may also have significant implications for quality of life, and management can be difficult due to rapid progression of disease and resistance to conventional therapies. In this article, we will review the published evidence for treatment modalities for melanoma-induced brain metastases and outline future directions for research. In brief, surgical management of solitary or acutely symptomatic lesions appears to alleviate symptoms and provide the possibility of local control of disease. Stereotactic radiosurgery is an increasingly utilized technique for patients with a limited number of metastases, and presents a less invasive alternative to craniotomy. External-beam radiation alone appears effective in palliating symptoms. Chemotherapy alone is relatively ineffective, though combined chemotherapy with external-beam radiation is being investigated. Future directions include combined-modality therapy, the incorporation of novel agents, and careful consideration of the structure of clinical trials for this disease.

Original languageEnglish (US)
Pages (from-to)743-755
Number of pages13
JournalExpert Review of Anticancer Therapy
Volume8
Issue number5
DOIs
StatePublished - 2008

Fingerprint

Melanoma
Neoplasm Metastasis
Brain
Radiation
Drug Therapy
Combined Modality Therapy
Disease Resistance
Radiosurgery
Craniotomy
Quality of Life
Clinical Trials
Therapeutics
Research
Direction compound

Keywords

  • Brain
  • Melanoma
  • Metastases
  • Radiosurgery
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

Cite this

Melanoma-induced brain metastases. / Mc Williams, Robert R; Rao, Ravi D.; Buckner, Jan Craig; Link, Michael J.; Markovic, Svetomir Nenad; Brown, Paul D.

In: Expert Review of Anticancer Therapy, Vol. 8, No. 5, 2008, p. 743-755.

Research output: Contribution to journalArticle

Mc Williams, Robert R ; Rao, Ravi D. ; Buckner, Jan Craig ; Link, Michael J. ; Markovic, Svetomir Nenad ; Brown, Paul D. / Melanoma-induced brain metastases. In: Expert Review of Anticancer Therapy. 2008 ; Vol. 8, No. 5. pp. 743-755.
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