Meige syndrome in the spectrum of Lewy body disease

M. H. Mark, J. I. Sage, Dennis W Dickson, R. E. Heikkila, L. Manzino, K. O. Schwarz, R. C. Duvoisin

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathologic changes of Parkinson's disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.

Original languageEnglish (US)
Pages (from-to)1432-1436
Number of pages5
JournalNeurology
Volume44
Issue number8
StatePublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Mark, M. H., Sage, J. I., Dickson, D. W., Heikkila, R. E., Manzino, L., Schwarz, K. O., & Duvoisin, R. C. (1994). Meige syndrome in the spectrum of Lewy body disease. Neurology, 44(8), 1432-1436.