Meeting report: Consensus Statement - Parkinson's disease and the environment: Collaborative on health and the environment and Parkinson's action network (CHE PAN) conference 26-28 June 2007

Jeff Bronstein, Paul Carvey, Honglei Chen, Deborah Cory-Slechta, Donato DiMonte, John Duda, Paul English, Samuel Goldman, Stephen Grate, Johnni Hanssen, Jane Hoppin, Sarah Jewell, Freya Kamel, Walter Koroshetz, James W. Langston, Giancarlo Logroscino, Lorene Nelson, Bernard Ravina, Walter Rocca, George W. RossTed Schettler, Michael Schwarzschild, Bill Scott, Richard Seegal, Andrew Singleton, Kyle Steenland, Caroline M. Tanner, Stephen van Den Eeden, Marc Weisskopf

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder. People with PD, their families, scientists, health care providers, and the general public are increasingly interested in identifying environmental contributors to PD risk. Methods: In June 2007, a multidisciplinary group of experts gathered in Sunnyvale, California, USA, to assess what is known about the contribution of environmental factors to PD. Results: We describe the conclusions around which they came to consensus with respect to environmental contributors to PD risk. We conclude with a brief summary of research needs. Conclusions: PD is a complex disorder, and multiple different pathogenic pathways and mechanisms can ultimately lead to PD. Within the individual there are many determinants of PD risk, and within populations, the causes of PD are heterogeneous. Although rare recognized genetic mutations are sufficient to cause PD, these account for < 10% of PD in the U.S. population, and incomplete penetrance suggests that environmental factors may be involved. Indeed, interplay among environmental factors and genetic makeup likely influences the risk of developing PD. There is a need for further understanding of how risk factors interact, and studying PD is likely to increase understanding of other neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)117-121
Number of pages5
JournalEnvironmental Health Perspectives
Volume117
Issue number1
DOIs
StatePublished - 2009

Keywords

  • Cholesterol
  • Coffee
  • Dairy products
  • Diet
  • Dopamine
  • Fatty acids
  • Metals
  • Nonsteroidal anti-inflammatory drugs
  • Parkinson's disease
  • Pesticides
  • Polychlorinated biphenyls
  • Smoking
  • Statins
  • Urate

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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    Bronstein, J., Carvey, P., Chen, H., Cory-Slechta, D., DiMonte, D., Duda, J., English, P., Goldman, S., Grate, S., Hanssen, J., Hoppin, J., Jewell, S., Kamel, F., Koroshetz, W., Langston, J. W., Logroscino, G., Nelson, L., Ravina, B., Rocca, W., ... Weisskopf, M. (2009). Meeting report: Consensus Statement - Parkinson's disease and the environment: Collaborative on health and the environment and Parkinson's action network (CHE PAN) conference 26-28 June 2007. Environmental Health Perspectives, 117(1), 117-121. https://doi.org/10.1289/ehp.11702