Medulloblastoma with glial and rhabdomyoblastic differentiation. A myoglobin and glial fibrillary acidic protein immunohistochemical and ultrastructural study

Dennis W Dickson, M. N. Hart, A. Menezes, P. A. Cancilla

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

This is a report of an unusual, densely cellular, midcerebellar neoplasm in a seven-year-old boy. Although clinically consistent with a medulloblastoma, immunohistochemistry and electron microscopy demonstrated glial and rhabdomyoblastic differentiation in the tumor. We discuss the differential diagnosis of this tumor as it relates to glial differentiation in medulloblastomas and the myogenic potential of primitive neuroectoderm.

Original languageEnglish (US)
Pages (from-to)639-647
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume42
Issue number6
StatePublished - 1983
Externally publishedYes

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Medulloblastoma
Myoglobin
Glial Fibrillary Acidic Protein
Neuroglia
Neural Plate
Neoplasms
Electron Microscopy
Differential Diagnosis
Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

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AU - Hart, M. N.

AU - Menezes, A.

AU - Cancilla, P. A.

PY - 1983

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AB - This is a report of an unusual, densely cellular, midcerebellar neoplasm in a seven-year-old boy. Although clinically consistent with a medulloblastoma, immunohistochemistry and electron microscopy demonstrated glial and rhabdomyoblastic differentiation in the tumor. We discuss the differential diagnosis of this tumor as it relates to glial differentiation in medulloblastomas and the myogenic potential of primitive neuroectoderm.

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