Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways

Vahan Martirosian, Thomas C. Chen, Michelle Lin, Josh Neman

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Medulloblastomas are the most common malignant pediatric brain tumors. Over the past several decades, a wide range of tumor-centric studies have identified genes and their regulators within signaling pathways that promote medulloblastoma growth. This review aims to raise awareness that transdisciplinary research between developmental neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to medulloblastomas. By leveraging current advances in neurodevelopment, microenvironment (including secreted neuropeptides), neurotransmitters, and axon guidance cues, we can uncover novel mechanisms used by the nervous system to promote medulloblastoma growth and spread. This will ultimately result in development of improved strategies for cancer prevention and treatment of pediatric patients with this devastating disease.

Original languageEnglish (US)
Pages (from-to)1511-1519
Number of pages9
JournalJournal of Neuroscience Research
Volume94
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Medulloblastoma
Tumor Microenvironment
Nervous System
Pediatrics
Neoplasms
Neurobiology
Regulator Genes
Growth
Neuropeptides
Brain Neoplasms
Cues
Neurotransmitter Agents
Research
Therapeutics

Keywords

  • medulloblastoma
  • metastasis
  • microenvironment
  • neurodevelopment
  • tumor initiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Medulloblastoma initiation and spread : Where neurodevelopment, microenvironment and cancer cross pathways. / Martirosian, Vahan; Chen, Thomas C.; Lin, Michelle; Neman, Josh.

In: Journal of Neuroscience Research, Vol. 94, No. 12, 01.12.2016, p. 1511-1519.

Research output: Contribution to journalReview article

@article{cbc34873faef42a9878b669c929b3739,
title = "Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways",
abstract = "Medulloblastomas are the most common malignant pediatric brain tumors. Over the past several decades, a wide range of tumor-centric studies have identified genes and their regulators within signaling pathways that promote medulloblastoma growth. This review aims to raise awareness that transdisciplinary research between developmental neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to medulloblastomas. By leveraging current advances in neurodevelopment, microenvironment (including secreted neuropeptides), neurotransmitters, and axon guidance cues, we can uncover novel mechanisms used by the nervous system to promote medulloblastoma growth and spread. This will ultimately result in development of improved strategies for cancer prevention and treatment of pediatric patients with this devastating disease.",
keywords = "medulloblastoma, metastasis, microenvironment, neurodevelopment, tumor initiation",
author = "Vahan Martirosian and Chen, {Thomas C.} and Michelle Lin and Josh Neman",
year = "2016",
month = "12",
day = "1",
doi = "10.1002/jnr.23917",
language = "English (US)",
volume = "94",
pages = "1511--1519",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "12",

}

TY - JOUR

T1 - Medulloblastoma initiation and spread

T2 - Where neurodevelopment, microenvironment and cancer cross pathways

AU - Martirosian, Vahan

AU - Chen, Thomas C.

AU - Lin, Michelle

AU - Neman, Josh

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Medulloblastomas are the most common malignant pediatric brain tumors. Over the past several decades, a wide range of tumor-centric studies have identified genes and their regulators within signaling pathways that promote medulloblastoma growth. This review aims to raise awareness that transdisciplinary research between developmental neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to medulloblastomas. By leveraging current advances in neurodevelopment, microenvironment (including secreted neuropeptides), neurotransmitters, and axon guidance cues, we can uncover novel mechanisms used by the nervous system to promote medulloblastoma growth and spread. This will ultimately result in development of improved strategies for cancer prevention and treatment of pediatric patients with this devastating disease.

AB - Medulloblastomas are the most common malignant pediatric brain tumors. Over the past several decades, a wide range of tumor-centric studies have identified genes and their regulators within signaling pathways that promote medulloblastoma growth. This review aims to raise awareness that transdisciplinary research between developmental neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to medulloblastomas. By leveraging current advances in neurodevelopment, microenvironment (including secreted neuropeptides), neurotransmitters, and axon guidance cues, we can uncover novel mechanisms used by the nervous system to promote medulloblastoma growth and spread. This will ultimately result in development of improved strategies for cancer prevention and treatment of pediatric patients with this devastating disease.

KW - medulloblastoma

KW - metastasis

KW - microenvironment

KW - neurodevelopment

KW - tumor initiation

UR - http://www.scopus.com/inward/record.url?scp=84991696564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991696564&partnerID=8YFLogxK

U2 - 10.1002/jnr.23917

DO - 10.1002/jnr.23917

M3 - Review article

C2 - 27629382

AN - SCOPUS:84991696564

VL - 94

SP - 1511

EP - 1519

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 12

ER -