Medullary thyroid carcinoma

Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970

H. Gharib, W. M. McConahey, R. D. Tiegs, E. J. Bergstralh, J. R. Goellner, C. S. Grant, J. A. Van Heerden, G. W. Sizemore, Ian D Hay

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Abstract

We retrospectively reviewed the medical records of 65 consecutive patients with medullary thyroid carcinoma, who had had their primary surgical treatment at the Mayo Clinic during the years 1946 through 1970. Of these patients, 58 had sporadic and 7 had familial medullary thyroid carcinoma. Thyroid nodules were the most common initial manifestation. Near-total thyroidectomy was the most frequent initial operation. Survival was affected by the following factors: male sex, familial inheritance, size of the tumor, stage of the tumor (American Joint Committee on Cancer), and completeness of initial resection of the tumor. The mean duration of follow-up was 23.5 years, and the maximal follow-up was 36 years. Among 52 patients without initial distant metastatic involvement and with complete resection of the tumor, 20-year survival free of distant metastatic lesions was 81%. Overall 10- and 20-year survival rates were 63% and 44%, respectively. Because of the substantial morbidity and mortality associated with medullary thyroid carcinoma, early diagnosis and thorough initial resection of the tumor are important.

Original languageEnglish (US)
Pages (from-to)934-940
Number of pages7
JournalMayo Clinic Proceedings
Volume67
Issue number10
StatePublished - 1992
Externally publishedYes

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Neoplasms
Sex Factors
Thyroid Nodule
Survival
Thyroidectomy
Medical Records
Medullary Thyroid cancer
Early Diagnosis
Survival Rate
Morbidity
Mortality
Therapeutics
Familial medullary thyroid carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gharib, H., McConahey, W. M., Tiegs, R. D., Bergstralh, E. J., Goellner, J. R., Grant, C. S., ... Hay, I. D. (1992). Medullary thyroid carcinoma: Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. Mayo Clinic Proceedings, 67(10), 934-940.

Medullary thyroid carcinoma : Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. / Gharib, H.; McConahey, W. M.; Tiegs, R. D.; Bergstralh, E. J.; Goellner, J. R.; Grant, C. S.; Van Heerden, J. A.; Sizemore, G. W.; Hay, Ian D.

In: Mayo Clinic Proceedings, Vol. 67, No. 10, 1992, p. 934-940.

Research output: Contribution to journalArticle

Gharib, H, McConahey, WM, Tiegs, RD, Bergstralh, EJ, Goellner, JR, Grant, CS, Van Heerden, JA, Sizemore, GW & Hay, ID 1992, 'Medullary thyroid carcinoma: Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970', Mayo Clinic Proceedings, vol. 67, no. 10, pp. 934-940.
Gharib H, McConahey WM, Tiegs RD, Bergstralh EJ, Goellner JR, Grant CS et al. Medullary thyroid carcinoma: Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. Mayo Clinic Proceedings. 1992;67(10):934-940.
Gharib, H. ; McConahey, W. M. ; Tiegs, R. D. ; Bergstralh, E. J. ; Goellner, J. R. ; Grant, C. S. ; Van Heerden, J. A. ; Sizemore, G. W. ; Hay, Ian D. / Medullary thyroid carcinoma : Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. In: Mayo Clinic Proceedings. 1992 ; Vol. 67, No. 10. pp. 934-940.
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