Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

Original languageEnglish (US)
Pages (from-to)168-177
Number of pages10
JournalAlzheimer's and Dementia
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Mediterranean Diet
Micronutrients
Parietal Lobe
Fabaceae
Fishes
Gyrus Cinguli
Tongue
Neuroimaging
Biomarkers
Carbohydrates
Magnetic Resonance Imaging
Prospective Studies

Keywords

  • Biomarkers
  • Cortical thickness
  • Cross-sectional studies
  • Diet
  • Fish
  • Fruit
  • Legumes
  • Macronutrients
  • Magnetic resonance imaging
  • Nutrition
  • Structural brain changes
  • Sugar
  • Vitamins

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

@article{593533f006754ca8b50a353959eccbc4,
title = "Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness",
abstract = "Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5{\%} men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.",
keywords = "Biomarkers, Cortical thickness, Cross-sectional studies, Diet, Fish, Fruit, Legumes, Macronutrients, Magnetic resonance imaging, Nutrition, Structural brain changes, Sugar, Vitamins",
author = "Staubo, {Sara C.} and Aakre, {Jeremiah A.} and Vemuri, {Prashanthi D} and Syrjanen, {Jeremy A.} and Mielke, {Michelle M} and Geda, {Yonas Endale} and Kremers, {Walter K} and Machulda, {Mary Margaret} and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Roberts, {Rosebud O}",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.jalz.2016.06.2359",
language = "English (US)",
volume = "13",
pages = "168--177",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

AU - Staubo, Sara C.

AU - Aakre, Jeremiah A.

AU - Vemuri, Prashanthi D

AU - Syrjanen, Jeremy A.

AU - Mielke, Michelle M

AU - Geda, Yonas Endale

AU - Kremers, Walter K

AU - Machulda, Mary Margaret

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Roberts, Rosebud O

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

AB - Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

KW - Biomarkers

KW - Cortical thickness

KW - Cross-sectional studies

KW - Diet

KW - Fish

KW - Fruit

KW - Legumes

KW - Macronutrients

KW - Magnetic resonance imaging

KW - Nutrition

KW - Structural brain changes

KW - Sugar

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=85013078039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013078039&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2016.06.2359

DO - 10.1016/j.jalz.2016.06.2359

M3 - Article

VL - 13

SP - 168

EP - 177

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 2

ER -