Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers

Maria Vassilaki, Jeremiah A. Aakre, Jeremy A. Syrjanen, Michelle M Mielke, Yonas Endale Geda, Walter K Kremers, Mary Margaret Machulda, Rabe E. Alhurani, Sara C. Staubo, David S Knopman, Ronald Carl Petersen, Val Lowe, Clifford R Jr. Jack, Rosebud O Roberts

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood. Objectives: To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11 C-PiB-PET scan measures of amyloid-β (Aβ) deposition. Methods: The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ϵ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake. Results: Participants' median age at FFQ was 77.7 years (55.8% men; 26.6% with an APOE ϵ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11 C-PiB standardized uptake value ratio. Conclusion: Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalJournal of Alzheimer's Disease
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Mediterranean Diet
Amyloid
Biomarkers
Food
Apolipoprotein E4
Vegetables
Positron-Emission Tomography
Linear Models
Logistic Models
Alleles
Sex Education
Micronutrients
beta Carotene
Energy Intake
Vitamin A
Neuroimaging
Alcohol Drinking
Dementia
Surveys and Questionnaires
Prospective Studies

Keywords

  • Amyloid
  • cross-sectional study
  • Mediterranean diet
  • vegetables

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. / Vassilaki, Maria; Aakre, Jeremiah A.; Syrjanen, Jeremy A.; Mielke, Michelle M; Geda, Yonas Endale; Kremers, Walter K; Machulda, Mary Margaret; Alhurani, Rabe E.; Staubo, Sara C.; Knopman, David S; Petersen, Ronald Carl; Lowe, Val; Jack, Clifford R Jr.; Roberts, Rosebud O.

In: Journal of Alzheimer's Disease, Vol. 64, No. 1, 01.01.2018, p. 281-290.

Research output: Contribution to journalArticle

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abstract = "Background: There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood. Objectives: To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11 C-PiB-PET scan measures of amyloid-β (Aβ) deposition. Methods: The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ϵ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake. Results: Participants' median age at FFQ was 77.7 years (55.8{\%} men; 26.6{\%} with an APOE ϵ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11 C-PiB standardized uptake value ratio. Conclusion: Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings.",
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AU - Vassilaki, Maria

AU - Aakre, Jeremiah A.

AU - Syrjanen, Jeremy A.

AU - Mielke, Michelle M

AU - Geda, Yonas Endale

AU - Kremers, Walter K

AU - Machulda, Mary Margaret

AU - Alhurani, Rabe E.

AU - Staubo, Sara C.

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Lowe, Val

AU - Jack, Clifford R Jr.

AU - Roberts, Rosebud O

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