TY - JOUR
T1 - Mediterranean diet and breast density in the Minnesota breast cancer family study
AU - Tseng, Marilyn
AU - Sellers, Thomas A.
AU - Vierkant, Robert A.
AU - Kushi, Lawrence H.
AU - Vachon, Celine M.
N1 - Funding Information:
The authors thank Ms. Fang-Fang Wu for her work in reading mammograms and estimation of mammographic percent density. This work was supported by Grant 5 R03 CA097779-02 from the National Institutes of Health.
PY - 2008/11
Y1 - 2008/11
N2 - Mediterranean populations' lower breast cancer incidence has been attributed to a traditional Mediterranean diet, but few studies have quantified Mediterranean dietary pattern intake in relation to breast cancer. We examined the association of a Mediterranean diet scale (MDS) with mammographic breast density as a surrogate marker for breast cancer risk. Participants completed a dietary questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. Among 1,286 women, MDS was not clearly associated with percent density in multivariate linear regression analyses. Because of previous work suggesting dietary effects limited to smokers, we conducted stratified analyses and found MDS and percent density to be significantly, inversely associated among current smokers (β = -1.68, P = 0.002) but not among nonsmokers (β = -0.08, P = 0.72; P for interaction = 0.008). Our results confirm a previous suggestion that selected dietary patterns may be protective primarily in the presence of procarcinogenic compounds such as those found in tobacco smoke.
AB - Mediterranean populations' lower breast cancer incidence has been attributed to a traditional Mediterranean diet, but few studies have quantified Mediterranean dietary pattern intake in relation to breast cancer. We examined the association of a Mediterranean diet scale (MDS) with mammographic breast density as a surrogate marker for breast cancer risk. Participants completed a dietary questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. Among 1,286 women, MDS was not clearly associated with percent density in multivariate linear regression analyses. Because of previous work suggesting dietary effects limited to smokers, we conducted stratified analyses and found MDS and percent density to be significantly, inversely associated among current smokers (β = -1.68, P = 0.002) but not among nonsmokers (β = -0.08, P = 0.72; P for interaction = 0.008). Our results confirm a previous suggestion that selected dietary patterns may be protective primarily in the presence of procarcinogenic compounds such as those found in tobacco smoke.
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U2 - 10.1080/01635580802233991
DO - 10.1080/01635580802233991
M3 - Article
C2 - 19005969
AN - SCOPUS:56249147013
SN - 0163-5581
VL - 60
SP - 703
EP - 709
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 6
ER -