TY - JOUR
T1 - Medicine
T2 - Tau suppression in a neurodegenerative mouse model improves memory function
AU - Santacruz, K.
AU - Lewis, J.
AU - Spires, T.
AU - Paulson, J.
AU - Kotilinek, L.
AU - Ingelsson, M.
AU - Guimaraes, A.
AU - DeTure, M.
AU - Ramsden, M.
AU - McCowan, E.
AU - Forster, C.
AU - Yue, M.
AU - Orne, J.
AU - Janus, C.
AU - Mariash, A.
AU - Kuskowski, M.
AU - Hyman, B.
AU - Hutton, M.
AU - Ashe, K. H.
PY - 2005/7/15
Y1 - 2005/7/15
N2 - Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.
AB - Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.
UR - http://www.scopus.com/inward/record.url?scp=22344438508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22344438508&partnerID=8YFLogxK
U2 - 10.1126/science.1113694
DO - 10.1126/science.1113694
M3 - Article
C2 - 16020737
AN - SCOPUS:22344438508
SN - 0036-8075
VL - 309
SP - 476
EP - 481
JO - Science
JF - Science
IS - 5733
ER -