Medical Treatments of GERD. The Old and New

Marcelo F. Vela

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The mainstay of pharmacological therapy for GERD is gastric acid suppression with proton pump inhibitors (PPIs), which are superior to histamine-2 receptor antagonists for healing erosive esophagitis and achieving symptomatic relief. However, up to one-third of patients may not respond to PPI therapy, creating the need for alternative treatments. Potential approaches include transient lower esophageal sphincter relaxation inhibitors, augmentation esophageal defense mechanisms by improving esophageal clearance or enhancing epithelial repair, and modulation of sensory pathways responsible for GERD symptoms. This review discusses the effectiveness of acid suppression and the data on alternative pharmacological approaches for the treatment of GERD.

Original languageEnglish (US)
Pages (from-to)121-133
Number of pages13
JournalGastroenterology Clinics of North America
Volume43
Issue number1
DOIs
StatePublished - Mar 2014
Externally publishedYes

Fingerprint

Gastroesophageal Reflux
Proton Pump Inhibitors
Pharmacology
Histamine Receptors
Lower Esophageal Sphincter
Esophagitis
Gastric Acid
Therapeutics
Acids

Keywords

  • Esophageal mucosal repair
  • Gastroesophageal reflux
  • Prokinetics
  • Proton pump inhibitors
  • Transient lower esophageal sphincter relaxation inhibitors
  • Visceral analgesia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Medical Treatments of GERD. The Old and New. / Vela, Marcelo F.

In: Gastroenterology Clinics of North America, Vol. 43, No. 1, 03.2014, p. 121-133.

Research output: Contribution to journalReview article

Vela, Marcelo F. / Medical Treatments of GERD. The Old and New. In: Gastroenterology Clinics of North America. 2014 ; Vol. 43, No. 1. pp. 121-133.
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