Medical sedation and sleep apnea

Mithri R. Junna; Bernardo J. Selim; Timothy I. Morgenthaler

doi:10.1016/j.jsmc.2012.11.012

Medical sedation and sleep apnea

Mithri R. Junna, Bernardo J. Selim, Timothy I. Morgenthaler

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The effects of hypnosedatives and opioids on breathing control may share common pathophysiologic pathways with obstructive sleep apnea (OSA), resulting in additive adverse consequences. Current understanding of the complex interaction of these medications across multiple systems is not only limited to muscle tone and anatomic considerations but also to dynamic ventilatory control and how they modulate the sleep state. This review article provides a systematic review of the most recent clinical and pharmacologic literature published regarding the effects of opioids and hypnosedatives on the clinical manifestation of OSA.

Original language	English (US)
Pages (from-to)	43-58
Number of pages	16
Journal	Sleep Medicine Clinics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.jsmc.2012.11.012
State	Published - Mar 2013

Keywords

Benzodiazepines
Hypnotics
Non-benzodiazepine GABA receptor agonists
Obstructive sleep apnea
Opioids
Sedation
Sleep architecture
Sleep-disordered breathing

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Clinical Psychology
Clinical Neurology
Psychiatry and Mental health

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10.1016/j.jsmc.2012.11.012

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title = "Medical sedation and sleep apnea",

abstract = "The effects of hypnosedatives and opioids on breathing control may share common pathophysiologic pathways with obstructive sleep apnea (OSA), resulting in additive adverse consequences. Current understanding of the complex interaction of these medications across multiple systems is not only limited to muscle tone and anatomic considerations but also to dynamic ventilatory control and how they modulate the sleep state. This review article provides a systematic review of the most recent clinical and pharmacologic literature published regarding the effects of opioids and hypnosedatives on the clinical manifestation of OSA.",

keywords = "Benzodiazepines, Hypnotics, Non-benzodiazepine GABA receptor agonists, Obstructive sleep apnea, Opioids, Sedation, Sleep architecture, Sleep-disordered breathing",

author = "Junna, {Mithri R.} and Selim, {Bernardo J.} and Morgenthaler, {Timothy I.}",

year = "2013",

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AU - Junna, Mithri R.

AU - Selim, Bernardo J.

AU - Morgenthaler, Timothy I.

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N2 - The effects of hypnosedatives and opioids on breathing control may share common pathophysiologic pathways with obstructive sleep apnea (OSA), resulting in additive adverse consequences. Current understanding of the complex interaction of these medications across multiple systems is not only limited to muscle tone and anatomic considerations but also to dynamic ventilatory control and how they modulate the sleep state. This review article provides a systematic review of the most recent clinical and pharmacologic literature published regarding the effects of opioids and hypnosedatives on the clinical manifestation of OSA.

AB - The effects of hypnosedatives and opioids on breathing control may share common pathophysiologic pathways with obstructive sleep apnea (OSA), resulting in additive adverse consequences. Current understanding of the complex interaction of these medications across multiple systems is not only limited to muscle tone and anatomic considerations but also to dynamic ventilatory control and how they modulate the sleep state. This review article provides a systematic review of the most recent clinical and pharmacologic literature published regarding the effects of opioids and hypnosedatives on the clinical manifestation of OSA.

KW - Benzodiazepines

KW - Hypnotics

KW - Non-benzodiazepine GABA receptor agonists

KW - Obstructive sleep apnea

KW - Opioids

KW - Sedation

KW - Sleep architecture

KW - Sleep-disordered breathing

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DO - 10.1016/j.jsmc.2012.11.012

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JO - Sleep Medicine Clinics

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Medical sedation and sleep apnea

Abstract

Keywords

ASJC Scopus subject areas

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