TY - JOUR
T1 - Medical history, lifestyle, family history, and occupational risk factors for sporadic Burkitt lymphoma/leukemia
T2 - The InterLymph non-Hodgkin lymphoma subtypes project
AU - Mbulaiteye, Sam M.
AU - Morton, Lindsay M.
AU - Sampson, Joshua N.
AU - Chang, Ellen T.
AU - Costas, Laura
AU - de Sanjosé, Silvia
AU - Lightfoot, Tracy
AU - Kelly, Jennifer
AU - Friedberg, Jonathan W.
AU - Cozen, Wendy
AU - Marcos-Gragera, Rafael
AU - Slager, Susan L.
AU - Birmann, Brenda M.
AU - Weisenburger, Dennis D.
PY - 2014/8
Y1 - 2014/8
N2 - Background: The etiologic role of medical history, lifestyle, family history, and occupational risk factors in sporadic Burkitt lymphoma (BL) is unknown, but epidemiologic and clinical evidence suggests that risk factors may vary by age. Methods: We investigated risk factors for sporadic BL in 295 cases compared with 21 818 controls in a pooled analysis of 18 case-control studies in the International Lymphoma Epidemiology Consortium (InterLymph). Cases were defined to include typical BL or Burkitt-like lymphoma. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations were calculated separately for younger (<50 years) and older (≥50 years) BL using multivariate logistic regression. Results: Cases included 133 younger BL and 159 older BL (age was missing for three cases) and they were evenly split between typical BL (n = 147) and Burkitt-like lymphoma (n = 148). BL in younger participants was inversely associated with a history of allergy (OR = 0.58; 95% CI = 0.32 to 1.05), and positively associated with a history of eczema among individuals without other atopic conditions (OR = 2.54; 95% CI = 1.20 to 5.40), taller height (OR = 2.17; 95% CI = 1.08 to 4.36), and employment as a cleaner (OR = 3.49; 95% CI = 1.13 to 10.7). BL in older participants was associated with a history of hepatitis C virus seropositivity (OR = 4.19; 95% CI = 1.05 to 16.6) based on three exposed cases. Regardless of age, BL was inversely associated with alcohol consumption and positively associated with height. Conclusions: Our data suggest that BL in younger and older adults may be etiologically distinct.
AB - Background: The etiologic role of medical history, lifestyle, family history, and occupational risk factors in sporadic Burkitt lymphoma (BL) is unknown, but epidemiologic and clinical evidence suggests that risk factors may vary by age. Methods: We investigated risk factors for sporadic BL in 295 cases compared with 21 818 controls in a pooled analysis of 18 case-control studies in the International Lymphoma Epidemiology Consortium (InterLymph). Cases were defined to include typical BL or Burkitt-like lymphoma. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations were calculated separately for younger (<50 years) and older (≥50 years) BL using multivariate logistic regression. Results: Cases included 133 younger BL and 159 older BL (age was missing for three cases) and they were evenly split between typical BL (n = 147) and Burkitt-like lymphoma (n = 148). BL in younger participants was inversely associated with a history of allergy (OR = 0.58; 95% CI = 0.32 to 1.05), and positively associated with a history of eczema among individuals without other atopic conditions (OR = 2.54; 95% CI = 1.20 to 5.40), taller height (OR = 2.17; 95% CI = 1.08 to 4.36), and employment as a cleaner (OR = 3.49; 95% CI = 1.13 to 10.7). BL in older participants was associated with a history of hepatitis C virus seropositivity (OR = 4.19; 95% CI = 1.05 to 16.6) based on three exposed cases. Regardless of age, BL was inversely associated with alcohol consumption and positively associated with height. Conclusions: Our data suggest that BL in younger and older adults may be etiologically distinct.
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U2 - 10.1093/jncimonographs/lgu003
DO - 10.1093/jncimonographs/lgu003
M3 - Article
C2 - 25174031
AN - SCOPUS:84906832197
SN - 1052-6773
SP - 106
EP - 114
JO - Journal of the National Cancer Institute - Monographs
JF - Journal of the National Cancer Institute - Monographs
IS - 48
ER -