Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: The interlymph non-hodgkin lymphoma subtypes project

Martha S. Linet, Claire M. Vajdic, Lindsay M. Morton, Anneclaire J. De Roos, Christine F. Skibola, Paolo Boffetta, James R Cerhan, Christopher R. Flowers, Silvia De Sanjosé, Alain Monnereau, Pierluigi Cocco, Jennifer L. Kelly, Alexandra G. Smith, Dennis D. Weisenburger, Christina A. Clarke, Aaron Blair, Leslie Bernstein, Tongzhang Zheng, Lucia Miligi, Jacqueline ClavelYolanda Benavente, Brian C H Chiu

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors. Methods: We assessed associations of medical, hormonal, family history, lifestyle, and occupational factors with FL risk in 3530 cases and 22 639 controls from 19 case-control studies in the InterLymph consortium. Age-, race/ethnicity-, sex- and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. Results: Most risk factors that were evaluated showed no association, except for a few modest or sex-specific relationships. FL risk was increased in persons: with a first-degree relative with non-Hodgkin lymphoma (OR = 1.99; 95% CI = 1.55 to 2.54); with greater body mass index as a young adult (OR = 1.15; 95% CI = 1.04 to 1.27 per 5 kg/ m2 increase); who worked as spray painters (OR = 2.66; 95% CI = 1.36 to 5.24); and among women with Sjögren syndrome (OR = 3.37; 95% CI = 1.23 to 9.19). Lower FL risks were observed in persons: with asthma, hay fever, and food allergy (ORs = 0.79-0.85); blood transfusions (OR = 0.78; 95% CI = 0.68 to 0.89); high recreational sun exposure (OR = 0.74; 95% CI = 0.65 to 0.86, fourth vs first quartile); who worked as bakers or millers (OR = 0.51; 95% CI = 0.28 to 0.93) or university/higher education teachers (OR = 0.58; 95% CI = 0.41 to 0.83). Elevated risks specific to women included current and longer duration of cigarette use, whereas reduced risks included current alcohol use, hay fever, and food allergies. Other factors, including other autoimmune diseases, eczema, hepatitis C virus seropositivity, hormonal drugs, hair dye use, sun exposure, and farming, were not associated with FL risk. Conclusions: The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence.

Original languageEnglish (US)
Pages (from-to)26-40
Number of pages15
JournalJournal of the National Cancer Institute - Monographs
Issue number48
DOIs
StatePublished - 2014

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Medical History Taking
Follicular Lymphoma
Non-Hodgkin's Lymphoma
Life Style
Odds Ratio
Confidence Intervals
Seasonal Allergic Rhinitis
Food Hypersensitivity
Solar System
Hair Dyes
Eczema
Agriculture
Tobacco Products
Blood Transfusion
Hepacivirus
Autoimmune Diseases
Case-Control Studies
Young Adult

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma : The interlymph non-hodgkin lymphoma subtypes project. / Linet, Martha S.; Vajdic, Claire M.; Morton, Lindsay M.; De Roos, Anneclaire J.; Skibola, Christine F.; Boffetta, Paolo; Cerhan, James R; Flowers, Christopher R.; De Sanjosé, Silvia; Monnereau, Alain; Cocco, Pierluigi; Kelly, Jennifer L.; Smith, Alexandra G.; Weisenburger, Dennis D.; Clarke, Christina A.; Blair, Aaron; Bernstein, Leslie; Zheng, Tongzhang; Miligi, Lucia; Clavel, Jacqueline; Benavente, Yolanda; Chiu, Brian C H.

In: Journal of the National Cancer Institute - Monographs, No. 48, 2014, p. 26-40.

Research output: Contribution to journalArticle

Linet, MS, Vajdic, CM, Morton, LM, De Roos, AJ, Skibola, CF, Boffetta, P, Cerhan, JR, Flowers, CR, De Sanjosé, S, Monnereau, A, Cocco, P, Kelly, JL, Smith, AG, Weisenburger, DD, Clarke, CA, Blair, A, Bernstein, L, Zheng, T, Miligi, L, Clavel, J, Benavente, Y & Chiu, BCH 2014, 'Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: The interlymph non-hodgkin lymphoma subtypes project', Journal of the National Cancer Institute - Monographs, no. 48, pp. 26-40. https://doi.org/10.1093/jncimonographs/lgu006
Linet, Martha S. ; Vajdic, Claire M. ; Morton, Lindsay M. ; De Roos, Anneclaire J. ; Skibola, Christine F. ; Boffetta, Paolo ; Cerhan, James R ; Flowers, Christopher R. ; De Sanjosé, Silvia ; Monnereau, Alain ; Cocco, Pierluigi ; Kelly, Jennifer L. ; Smith, Alexandra G. ; Weisenburger, Dennis D. ; Clarke, Christina A. ; Blair, Aaron ; Bernstein, Leslie ; Zheng, Tongzhang ; Miligi, Lucia ; Clavel, Jacqueline ; Benavente, Yolanda ; Chiu, Brian C H. / Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma : The interlymph non-hodgkin lymphoma subtypes project. In: Journal of the National Cancer Institute - Monographs. 2014 ; No. 48. pp. 26-40.
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abstract = "Background: Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors. Methods: We assessed associations of medical, hormonal, family history, lifestyle, and occupational factors with FL risk in 3530 cases and 22 639 controls from 19 case-control studies in the InterLymph consortium. Age-, race/ethnicity-, sex- and study-adjusted odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using logistic regression. Results: Most risk factors that were evaluated showed no association, except for a few modest or sex-specific relationships. FL risk was increased in persons: with a first-degree relative with non-Hodgkin lymphoma (OR = 1.99; 95{\%} CI = 1.55 to 2.54); with greater body mass index as a young adult (OR = 1.15; 95{\%} CI = 1.04 to 1.27 per 5 kg/ m2 increase); who worked as spray painters (OR = 2.66; 95{\%} CI = 1.36 to 5.24); and among women with Sj{\"o}gren syndrome (OR = 3.37; 95{\%} CI = 1.23 to 9.19). Lower FL risks were observed in persons: with asthma, hay fever, and food allergy (ORs = 0.79-0.85); blood transfusions (OR = 0.78; 95{\%} CI = 0.68 to 0.89); high recreational sun exposure (OR = 0.74; 95{\%} CI = 0.65 to 0.86, fourth vs first quartile); who worked as bakers or millers (OR = 0.51; 95{\%} CI = 0.28 to 0.93) or university/higher education teachers (OR = 0.58; 95{\%} CI = 0.41 to 0.83). Elevated risks specific to women included current and longer duration of cigarette use, whereas reduced risks included current alcohol use, hay fever, and food allergies. Other factors, including other autoimmune diseases, eczema, hepatitis C virus seropositivity, hormonal drugs, hair dye use, sun exposure, and farming, were not associated with FL risk. Conclusions: The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence.",
author = "Linet, {Martha S.} and Vajdic, {Claire M.} and Morton, {Lindsay M.} and {De Roos}, {Anneclaire J.} and Skibola, {Christine F.} and Paolo Boffetta and Cerhan, {James R} and Flowers, {Christopher R.} and {De Sanjos{\'e}}, Silvia and Alain Monnereau and Pierluigi Cocco and Kelly, {Jennifer L.} and Smith, {Alexandra G.} and Weisenburger, {Dennis D.} and Clarke, {Christina A.} and Aaron Blair and Leslie Bernstein and Tongzhang Zheng and Lucia Miligi and Jacqueline Clavel and Yolanda Benavente and Chiu, {Brian C H}",
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T1 - Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma

T2 - The interlymph non-hodgkin lymphoma subtypes project

AU - Linet, Martha S.

AU - Vajdic, Claire M.

AU - Morton, Lindsay M.

AU - De Roos, Anneclaire J.

AU - Skibola, Christine F.

AU - Boffetta, Paolo

AU - Cerhan, James R

AU - Flowers, Christopher R.

AU - De Sanjosé, Silvia

AU - Monnereau, Alain

AU - Cocco, Pierluigi

AU - Kelly, Jennifer L.

AU - Smith, Alexandra G.

AU - Weisenburger, Dennis D.

AU - Clarke, Christina A.

AU - Blair, Aaron

AU - Bernstein, Leslie

AU - Zheng, Tongzhang

AU - Miligi, Lucia

AU - Clavel, Jacqueline

AU - Benavente, Yolanda

AU - Chiu, Brian C H

PY - 2014

Y1 - 2014

N2 - Background: Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors. Methods: We assessed associations of medical, hormonal, family history, lifestyle, and occupational factors with FL risk in 3530 cases and 22 639 controls from 19 case-control studies in the InterLymph consortium. Age-, race/ethnicity-, sex- and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. Results: Most risk factors that were evaluated showed no association, except for a few modest or sex-specific relationships. FL risk was increased in persons: with a first-degree relative with non-Hodgkin lymphoma (OR = 1.99; 95% CI = 1.55 to 2.54); with greater body mass index as a young adult (OR = 1.15; 95% CI = 1.04 to 1.27 per 5 kg/ m2 increase); who worked as spray painters (OR = 2.66; 95% CI = 1.36 to 5.24); and among women with Sjögren syndrome (OR = 3.37; 95% CI = 1.23 to 9.19). Lower FL risks were observed in persons: with asthma, hay fever, and food allergy (ORs = 0.79-0.85); blood transfusions (OR = 0.78; 95% CI = 0.68 to 0.89); high recreational sun exposure (OR = 0.74; 95% CI = 0.65 to 0.86, fourth vs first quartile); who worked as bakers or millers (OR = 0.51; 95% CI = 0.28 to 0.93) or university/higher education teachers (OR = 0.58; 95% CI = 0.41 to 0.83). Elevated risks specific to women included current and longer duration of cigarette use, whereas reduced risks included current alcohol use, hay fever, and food allergies. Other factors, including other autoimmune diseases, eczema, hepatitis C virus seropositivity, hormonal drugs, hair dye use, sun exposure, and farming, were not associated with FL risk. Conclusions: The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence.

AB - Background: Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors. Methods: We assessed associations of medical, hormonal, family history, lifestyle, and occupational factors with FL risk in 3530 cases and 22 639 controls from 19 case-control studies in the InterLymph consortium. Age-, race/ethnicity-, sex- and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. Results: Most risk factors that were evaluated showed no association, except for a few modest or sex-specific relationships. FL risk was increased in persons: with a first-degree relative with non-Hodgkin lymphoma (OR = 1.99; 95% CI = 1.55 to 2.54); with greater body mass index as a young adult (OR = 1.15; 95% CI = 1.04 to 1.27 per 5 kg/ m2 increase); who worked as spray painters (OR = 2.66; 95% CI = 1.36 to 5.24); and among women with Sjögren syndrome (OR = 3.37; 95% CI = 1.23 to 9.19). Lower FL risks were observed in persons: with asthma, hay fever, and food allergy (ORs = 0.79-0.85); blood transfusions (OR = 0.78; 95% CI = 0.68 to 0.89); high recreational sun exposure (OR = 0.74; 95% CI = 0.65 to 0.86, fourth vs first quartile); who worked as bakers or millers (OR = 0.51; 95% CI = 0.28 to 0.93) or university/higher education teachers (OR = 0.58; 95% CI = 0.41 to 0.83). Elevated risks specific to women included current and longer duration of cigarette use, whereas reduced risks included current alcohol use, hay fever, and food allergies. Other factors, including other autoimmune diseases, eczema, hepatitis C virus seropositivity, hormonal drugs, hair dye use, sun exposure, and farming, were not associated with FL risk. Conclusions: The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence.

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