Medical history, lifestyle, family history, and occupational risk factors for marginal zone lymphoma: The interLymph non-Hodgkin lymphoma subtypes project

Paige M. Bracci, Yolanda Benavente, Jennifer J. Turner, Ora Paltiel, Susan L. Slager, Claire M. Vajdic, Aaron D. Norman, James R. Cerhan, Brian C.H. Chiu, Nikolaus Becker, Pierluigi Cocco, Ahmet Dogan, Alexandra Nieters, Elizabeth A. Holly, Eleanor V. Kane, Karin E. Smedby, Marc Maynadié, John J. Spinelli, Eve Roman, Bengt GlimeliusSophia S. Wang, Joshua N. Sampson, Lindsay M. Morton, Silvia de Sanjosé

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Background: Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%-10% of non-Hodgkin lymphoma cases. A detailed evaluation of the independent effects of risk factors for MZL and its subtypes has not been conducted. Methods: Data were pooled from 1052 MZL cases (extranodal [EMZL] = 633, nodal [NMZL] = 157, splenic [SMZL] = 140) and 13 766 controls from 12 case-control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Results: Novel findings for MZL subtypes include increased risk for B-cell activating autoimmune conditions (EMZL OR = 6.40, 95% CI = 4.24 to 9.68; NMZL OR = 7.80, 95% CI = 3.32 to 18.33; SMZL OR = 4.25, 95% CI = 1.49 to 12.14), hepatitis C virus seropositivity (EMZL OR = 5.29, 95% CI = 2.48 to 11.28), self-reported peptic ulcers (EMZL OR = 1.83, 95% CI = 1.35 to 2.49), asthma without other atopy (SMZL OR = 2.28, 95% CI = 1.23 to 4.23), family history of hematologic cancer (EMZL OR = 1.90, 95% CI = 1.37 to 2.62) and of non-Hodgkin lymphoma (NMZL OR = 2.82, 95% CI = 1.33 to 5.98), permanent hairdye use (SMZL OR = 6.59, 95% CI = 1.54 to 28.17), and occupation as a metalworker (NMZL OR = 3.56, 95% CI = 1.67 to 7.58). Reduced risks were observed with consumption of any alcohol (EMZL fourth quartile OR = 0.48, 95% CI = 0.28 to 0.82) and lower consumption of wine (NMZL first to third quartile ORs < 0.45) compared with nondrinkers, and occupation as a teacher (EMZL OR = 0.58, 95% CI = 0.37 to 0.88). Conclusion: Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found.

Original languageEnglish (US)
Pages (from-to)52-65
Number of pages14
JournalJournal of the National Cancer Institute - Monographs
Issue number48
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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