Medical history, lifestyle, family history, and occupational risk factors for peripheral T-cell lymphomas: The interlymph non-hodgkin lymphoma subtypes project

Sophia S. Wang, Christopher R. Flowers, Marshall E. Kadin, Ellen T. Chang, Ann Maree Hughes, Stephen M. Ansell, Andrew L. Feldman, Tracy Lightfoot, Paolo Boffetta, Mads Melbye, Qing Lan, Joshua N. Sampson, Lindsay M. Morton, Yawei Zhang, Dennis D. Weisenburger

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Accounting for 10%-15% of all non-Hodgkin lymphomas in Western populations, peripheral T-cell lymphomas (PTCL) are the most common T-cell lymphoma but little is known about their etiology. Our aim was to identify etiologic risk factors for PTCL overall, and for specific PTCL subtypes, by analyzing data from 15 epidemiologic studies participating in the InterLymph Consortium. Methods: A pooled analysis of individual-level data for 584 histologically confirmed PTCL cases and 15 912 controls from 15 case-control studies conducted in Europe, North America, and Australia was undertaken. Data collected from questionnaires were harmonized to permit evaluation of a broad range of potential risk factors. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. Results: Risk factors associated with increased overall PTCL risk with a P value less than .05 included: a family history of hematologic malignancies (OR = 1.92, 95% CI = 1.30 to 2.84); celiac disease (OR = 17.8, 95% CI = 8.61 to 36.79); eczema (OR = 1.41, 95% CI = 1.07 to 1.85); psoriasis (OR = 1.97, 95% CI = 1.17 to 3.32); smoking 40 or more years (OR = 1.92, 95% CI = 1.41 to 2.62); and employment as a textile worker (ever) (OR = 1.58, 95% CI = 1.05 to 2.38) and electrical fitter (ever) (OR = 2.89, 95% CI = 1.41 to 5.95). Exposures associated with reduced overall PTCL risk included a personal history of allergies (OR = 0.69, 95% CI = 0.54 to 0.87), alcohol consumption (ever) (OR = 0.64, 95% CI = 0.49 to 0.82), and having ever lived or worked on a farm (OR = 0.72, 95% CI = 0.55% to 0.95%). We also observed the well-established risk elevation for enteropathy-type PTCL among those with celiac disease in our data. Conclusions: Our pooled analyses identified a number of new potential risk factors for PTCL and require further validation in independent series.

Original languageEnglish (US)
Pages (from-to)66-75
Number of pages10
JournalJournal of the National Cancer Institute - Monographs
Issue number48
DOIs
StatePublished - Aug 2014

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wang, S. S., Flowers, C. R., Kadin, M. E., Chang, E. T., Hughes, A. M., Ansell, S. M., Feldman, A. L., Lightfoot, T., Boffetta, P., Melbye, M., Lan, Q., Sampson, J. N., Morton, L. M., Zhang, Y., & Weisenburger, D. D. (2014). Medical history, lifestyle, family history, and occupational risk factors for peripheral T-cell lymphomas: The interlymph non-hodgkin lymphoma subtypes project. Journal of the National Cancer Institute - Monographs, (48), 66-75. https://doi.org/10.1093/jncimonographs/lgu012