Medical co-morbidity in depressive disorders

Tami Benton, Jeffrey P Staab, Dwight L. Evans

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Background. Depression is much more prevalent among those with chronic medical conditions compared to the general population of the United States. Depression is recognized as a cause of increased morbidity and mortality and has been associated with higher health care costs, adverse health behaviors, significant functional impairment, lost work productivity, occupational disability and increased health care utilization. Method. Searches of Medline, OVIDMedline, PubMed and PsycINFO of all English-language articles published between 1966 and 2007 were conducted using the keywords mood disorders, medical comorbidity, depression, antidepressant therapy. Supplemental references were manually extracted from relevant articles and chapters. Reviews of mechanistic studies and open label and randomized controlled trials of depression in patients with medical co morbidities were reviewed. Results. Depressive disorders are prevalent among the medically ill and the relationship between depression and medical illness may be bidirectional. Antidepressant medications are effective in the treatment of depression in the medically ill. Conclusions. Depressive disorders can adversely impact the course of medical illnesses. Available antidepressant treatments are effective for the treatment of depression in the medically ill. Early identification and treatment of depression in medical illness can positively influence medical outcomes and quality of life.

Original languageEnglish (US)
Pages (from-to)289-303
Number of pages15
JournalAnnals of Clinical Psychiatry
Volume19
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Depressive Disorder
Depression
Morbidity
Antidepressive Agents
Patient Acceptance of Health Care
Therapeutics
Health Behavior
Mood Disorders
PubMed
Health Care Costs
Comorbidity
Language
Randomized Controlled Trials
Quality of Life
Mortality
Population

Keywords

  • Depression
  • Medical comorbidity
  • Mood disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Medical co-morbidity in depressive disorders. / Benton, Tami; Staab, Jeffrey P; Evans, Dwight L.

In: Annals of Clinical Psychiatry, Vol. 19, No. 4, 10.2007, p. 289-303.

Research output: Contribution to journalArticle

Benton, Tami ; Staab, Jeffrey P ; Evans, Dwight L. / Medical co-morbidity in depressive disorders. In: Annals of Clinical Psychiatry. 2007 ; Vol. 19, No. 4. pp. 289-303.
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