Mediastinal granuloma and mediastinal fibrosis

James M. Parish, Edward C. Rosenow

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mediastinal granuloma/mediastinal fibrosis is a chronic inflammatory disease of the mediastinum. Mediastinal granuloma is the abnormal enlargement of mediastinal lymph nodes by granulomatous inflammation, is usually asyptomatic or minimally symptomatic, and is often detected on chest radiographs taken for other reasons. In contrast, mediastinal fibrosis is extensive fibrous tissue throughout the middle mediastinum causing compression, encasement, or invasion of the large bronchi, superior vena cava, pulmonary veins, or esophagus, often with serious clinical consequences. Some patients may exhibit a clinical entity characterized by enlarged fibrotic and/or calicified lymph nodes with a variable amount of fibrosis that may be asymptomatic, or may cause symptoms by compression or invasion of structures in the mediastinum. Clinical manifestations may be due to superior vena cava (SVC) obstruction, esophageal compression, large airway involvement, pulmonary artery or pulmonary vein narrowing, or laryngeal or phrenic nerve impingement. Definitive diagnosis is traditionally made on the basis of a surgical exploration and biopsy, either a mediastinoscopy or thoracotomy; however, characteristic findings on computed tomography (CT) of the chest may be sufficient for a diagnosis in a certain number of cases. The best therapy is unknown. Antifungal therapy and corticosteroids have been reported effective in some cases. Surgical resection of localized mediastinal granuloma or fibrosis causing symptoms is often effective. However, surgical resection of extensive mediastinal fibrosis usually is not feasible.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalSeminars in Respiratory and Critical Care Medicine
Volume23
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Mediastinum
Granuloma
Pulmonary Veins
Fibrosis
Thorax
Lymph Nodes
Laryngeal Nerves
Mediastinoscopy
Superior Vena Cava Syndrome
Phrenic Nerve
Superior Vena Cava
Thoracotomy
Bronchi
Pulmonary Artery
Esophagus
Adrenal Cortex Hormones
Chronic Disease
Tomography
Inflammation
Biopsy

Keywords

  • Fibrosing mediastinitis
  • Histoplasmosis
  • Mediastinal fibrosis
  • Mediastinal granuloma
  • Mediastinal, granulomatosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine
  • Critical Care

Cite this

Mediastinal granuloma and mediastinal fibrosis. / Parish, James M.; Rosenow, Edward C.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 23, No. 2, 2002, p. 135-143.

Research output: Contribution to journalArticle

Parish, James M. ; Rosenow, Edward C. / Mediastinal granuloma and mediastinal fibrosis. In: Seminars in Respiratory and Critical Care Medicine. 2002 ; Vol. 23, No. 2. pp. 135-143.
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