Medial temporal lobe functional connectivity predicts stimulation-induced theta power

E. A. Solomon; J. E. Kragel; R. Gross; B. Lega; M. R. Sperling; G. Worrell; S. A. Sheth; K. A. Zaghloul; B. C. Jobst; J. M. Stein; S. Das; R. Gorniak; C. S. Inman; S. Seger; D. S. Rizzuto; M. J. Kahana

doi:10.1038/s41467-018-06876-w

Medial temporal lobe functional connectivity predicts stimulation-induced theta power

E. A. Solomon, J. E. Kragel, R. Gross, B. Lega, M. R. Sperling, G. Worrell, S. A. Sheth, K. A. Zaghloul, B. C. Jobst, J. M. Stein, S. Das, R. Gorniak, C. S. Inman, S. Seger, D. S. Rizzuto, M. J. Kahana

Neurology

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16 Scopus citations

Abstract

Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5–13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5–8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50–200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.

Original language	English (US)
Article number	4437
Journal	Nature communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-06876-w
State	Published - Dec 1 2018

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Solomon, E. A., Kragel, J. E., Gross, R., Lega, B., Sperling, M. R., Worrell, G., Sheth, S. A., Zaghloul, K. A., Jobst, B. C., Stein, J. M., Das, S., Gorniak, R., Inman, C. S., Seger, S., Rizzuto, D. S., & Kahana, M. J. (2018). Medial temporal lobe functional connectivity predicts stimulation-induced theta power. Nature communications, 9(1), Article 4437. https://doi.org/10.1038/s41467-018-06876-w

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title = "Medial temporal lobe functional connectivity predicts stimulation-induced theta power",

abstract = "Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5–13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5–8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50–200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.",

author = "Solomon, {E. A.} and Kragel, {J. E.} and R. Gross and B. Lega and Sperling, {M. R.} and G. Worrell and Sheth, {S. A.} and Zaghloul, {K. A.} and Jobst, {B. C.} and Stein, {J. M.} and S. Das and R. Gorniak and Inman, {C. S.} and S. Seger and Rizzuto, {D. S.} and Kahana, {M. J.}",

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AU - Kragel, J. E.

AU - Gross, R.

AU - Lega, B.

AU - Sperling, M. R.

AU - Worrell, G.

AU - Sheth, S. A.

AU - Zaghloul, K. A.

AU - Jobst, B. C.

AU - Stein, J. M.

AU - Das, S.

AU - Gorniak, R.

AU - Inman, C. S.

AU - Seger, S.

AU - Rizzuto, D. S.

AU - Kahana, M. J.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5–13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5–8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50–200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.

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Medial temporal lobe functional connectivity predicts stimulation-induced theta power

Abstract

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