Mechanisms underlying T cell ageing

Jörg J. Goronzy, Cornelia M. Weyand

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy accessibility to peripheral human T cells as well as an expanding array of tools to examine T cell biology have provided opportunities to examine major ageing pathways and their consequences for T cell function. Here, we review emerging concepts of how the body attempts to maintain a functional T cell compartment with advancing age, focusing on three fundamental domains of the ageing process, namely self-renewal, control of cellular quiescence and cellular senescence. Understanding these critical elements in successful T cell ageing will allow the design of interventions to prevent or reverse ageing-related T cell failure.

Original languageEnglish (US)
Pages (from-to)573-583
Number of pages11
JournalNature Reviews Immunology
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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