Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

F. V. Brozovich, C. J. Nicholson, C. V. Degen, Yuan Z. Gao, M. Aggarwal, Kathleen G. Morgan

Research output: Contribution to journalReview article

132 Scopus citations

Abstract

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

Original languageEnglish (US)
Pages (from-to)476-532
Number of pages57
JournalPharmacological Reviews
Volume68
Issue number2
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G. (2016). Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. Pharmacological Reviews, 68(2), 476-532. https://doi.org/10.1124/pr.115.010652