Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

F. V. Brozovich, C. J. Nicholson, C. V. Degen, Yuan Z. Gao, M. Aggarwal, Kathleen G. Morgan

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

Original languageEnglish (US)
Pages (from-to)476-532
Number of pages57
JournalPharmacological Reviews
Volume68
Issue number2
DOIs
StatePublished - Apr 1 2016

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Muscular Diseases
Muscle Contraction
Vascular Smooth Muscle
Smooth Muscle
Blood Vessels
Smooth Muscle Myocytes
Precision Medicine
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G. (2016). Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. Pharmacological Reviews, 68(2), 476-532. https://doi.org/10.1124/pr.115.010652

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. / Brozovich, F. V.; Nicholson, C. J.; Degen, C. V.; Gao, Yuan Z.; Aggarwal, M.; Morgan, Kathleen G.

In: Pharmacological Reviews, Vol. 68, No. 2, 01.04.2016, p. 476-532.

Research output: Contribution to journalArticle

Brozovich, F. V. ; Nicholson, C. J. ; Degen, C. V. ; Gao, Yuan Z. ; Aggarwal, M. ; Morgan, Kathleen G. / Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. In: Pharmacological Reviews. 2016 ; Vol. 68, No. 2. pp. 476-532.
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