Mechanisms of neurotoxic injury and cell death

E. S. McDonald, Anthony John Windebank

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Neurotoxic injury to the nervous system usually produces neuronal death or distal axonal degeneration. Neurotoxin-induced demyelination is relatively rare in both the PNS and CNS. Major advances have occurred in our understanding of the mechanism of excitotoxic and apoptotic cell death. The pathways leading to apoptosis offer many new approaches to neuroprotection. The most promising is the use of specific neuronal growth factors (NGF, BDNF, NT3, IGF-I, etc.) to prevent neurotoxicity. All of these growth factors seem to be able to regulate the mitochondrial/cytochrome c pathway. The development of therapeutic strategies to prevent neurotoxic injury has broad implications. Many neurodegenerative and metabolic disorders of the nervous system probably involve similar death pathways. These mechanism-based approaches to preventing neurotoxic injury will generate potential therapies for other neurologic disorders. The chemotherapeutic neurotoxins are valuable models because prospective human trials are uniquely possible. Treatment can be administered before the neurotoxic insult is administered; usually under carefully controlled conditions.

Original languageEnglish (US)
Pages (from-to)525-540
Number of pages16
JournalNeurologic Clinics
Volume18
Issue number3
StatePublished - 2000

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Neurotoxins
Intercellular Signaling Peptides and Proteins
Cell Death
Nervous System Trauma
Brain-Derived Neurotrophic Factor
Wounds and Injuries
Demyelinating Diseases
Nerve Growth Factor
Cytochromes c
Nervous System Diseases
Insulin-Like Growth Factor I
Neurodegenerative Diseases
Nervous System
Apoptosis
Therapeutics
Neuroprotection

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Mechanisms of neurotoxic injury and cell death. / McDonald, E. S.; Windebank, Anthony John.

In: Neurologic Clinics, Vol. 18, No. 3, 2000, p. 525-540.

Research output: Contribution to journalArticle

McDonald, E. S. ; Windebank, Anthony John. / Mechanisms of neurotoxic injury and cell death. In: Neurologic Clinics. 2000 ; Vol. 18, No. 3. pp. 525-540.
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