Mechanisms of migraine aura revealed by functional MRI in human visual cortex

Nouchine Hadjikhani, Margarita Sanchez Del Rio, Ona Wu, Denis Schwartz, Dick Bakker, Bruce Fischl, Kenneth K. Kwong, F. Michael Cutrer, Bruce R. Rosen, R. B H Tootell, A. Gregory Sorensen, Michael A. Moskowitz

Research output: Contribution to journalArticle

967 Citations (Scopus)

Abstract

Cortical spreading depression (CSD) has been suggested to underlie migraine visual aura. However, it has been challenging to test this hypothesis in human cerebral cortex. Using high-field functional MRI with near-continuous recording during visual aura in three subjects, we observed blood oxygenation level-dependent (BOLD) signal changes that demonstrated at least eight characteristics of CSD, time-locked to percept/onset of the aura. Initially, a focal increase in BOLD signal (possibly reflecting vasodilation), developed within extrastriate cortex (area V3A). This BOLD change progressed contiguously and slowly (3.5 ± 1.1 mm/min) over occipital cortex, congruent with the retinotopy of the visual percept. Following the same retinotopic progression, the BOLD signal then diminished (possibly reflecting vasoconstriction after the initial vasodilation), as did the BOLD response to visual activation. During periods with no visual stimulation, but while the subject was experiencing scintillations, BOLD signal followed the retinotopic progression of the visual percept. These data strongly suggest that an electrophysiological event such as CSD generates the aura in human visual cortex.

Original languageEnglish (US)
Pages (from-to)4687-4692
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number8
DOIs
StatePublished - Apr 10 2001
Externally publishedYes

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Visual Cortex
Migraine Disorders
Epilepsy
Magnetic Resonance Imaging
Cortical Spreading Depression
Vasodilation
Occipital Lobe
Photic Stimulation
Vasoconstriction
Cerebral Cortex

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Hadjikhani, N., Sanchez Del Rio, M., Wu, O., Schwartz, D., Bakker, D., Fischl, B., ... Moskowitz, M. A. (2001). Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proceedings of the National Academy of Sciences of the United States of America, 98(8), 4687-4692. https://doi.org/10.1073/pnas.071582498

Mechanisms of migraine aura revealed by functional MRI in human visual cortex. / Hadjikhani, Nouchine; Sanchez Del Rio, Margarita; Wu, Ona; Schwartz, Denis; Bakker, Dick; Fischl, Bruce; Kwong, Kenneth K.; Cutrer, F. Michael; Rosen, Bruce R.; Tootell, R. B H; Sorensen, A. Gregory; Moskowitz, Michael A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 8, 10.04.2001, p. 4687-4692.

Research output: Contribution to journalArticle

Hadjikhani, N, Sanchez Del Rio, M, Wu, O, Schwartz, D, Bakker, D, Fischl, B, Kwong, KK, Cutrer, FM, Rosen, BR, Tootell, RBH, Sorensen, AG & Moskowitz, MA 2001, 'Mechanisms of migraine aura revealed by functional MRI in human visual cortex', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 8, pp. 4687-4692. https://doi.org/10.1073/pnas.071582498
Hadjikhani, Nouchine ; Sanchez Del Rio, Margarita ; Wu, Ona ; Schwartz, Denis ; Bakker, Dick ; Fischl, Bruce ; Kwong, Kenneth K. ; Cutrer, F. Michael ; Rosen, Bruce R. ; Tootell, R. B H ; Sorensen, A. Gregory ; Moskowitz, Michael A. / Mechanisms of migraine aura revealed by functional MRI in human visual cortex. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 8. pp. 4687-4692.
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