Mechanisms of Liver Injury

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The death of constituent cell populations of the liver is a central component of liver injury cascades. Hepatocytes are targeted by most injurious stimuli, though other cells types are affected as well. Cell death in the liver can occur via apoptosis or necrosis. Apoptosis can be initiated via death receptor-mediated pathways, the extrinsic pathway, or from intracellular perturbations, the intrinsic pathway. Mitochondrial permeabilization is required for hepatocyte apoptosis, and both intrinsic and extrinsic pathways converge on mitochondria. Effector caspases are activated downstream of mitochondria, and cleave several cellular targets to result in the characteristic apoptotic morphology. Dead cells release damage-associated molecular patterns that activate the innate immune system and downstream inflammatory cascades. Ongoing apoptosis in the liver stimulates Kupffer cells, and activates hepatic stellate cell-stimulating fibrosis. Therapies aimed at preventing hepatocyte apoptosis show promise in experimental and clinical settings.

Original languageEnglish (US)
Title of host publicationSchiff's Diseases of the Liver
PublisherWiley-Blackwell
Pages216-231
Number of pages16
ISBN (Print)0470654686, 9780470654682
DOIs
StatePublished - Oct 31 2011

Keywords

  • Apoptosis
  • Caspase
  • Fas
  • Liver injury
  • Mitochondrial permeabilization
  • Necrosis
  • TRAIL
  • Tumor necrosis factor α (TNF-α)

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Mechanisms of Liver Injury'. Together they form a unique fingerprint.

Cite this