Mechanisms of injury to the preterm lung and airway: Implications for long-term pulmonary outcome

Brent Reyburn, Richard J. Martin, Y.s. Prakash, Peter M. MacFarlane

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Despite changes in the epidemiology of bronchopulmonary dysplasia (BPD), longer-term morbidity, particularly in the form of airway dysfunction, remains a substantial problem in former preterm infants. The stage for this respiratory morbidity may begin as early as the transition from fetal to neonatal life. Newer therapeutic approaches for BPD should be directed toward minimizing this longer-term respiratory morbidity. Neonatal animal models focused primarily on hyperoxic exposure may provide important insights into the pathogenesis of longer-term airway hyperreactivity in this population.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalNeonatology
Volume101
Issue number4
DOIs
StatePublished - Jun 2012

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Keywords

  • Bronchopulmonary dysplasia
  • Neonatal airway function
  • Pediatric asthma

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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