Mechanisms of hypersensitivity in IBS and functional disorders

F. Azpiroz, M. Bouin, Michael Camilleri, E. A. Mayer, P. Poitras, J. Serra, R. C. Spiller

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

General introduction: The concept of visceral hypersensitivity is accepted as being germane to several functional gastrointestinal disorders (FGIDs). The causes or risk factors associated with this hypersensitivity are unclear. This article addresses the proposed mechanisms leading to hypersensitivity: from genetic to inflammatory disorders, from central to peripheral alterations of function. However, in order to place visceral hypersensitivity in a more global perspective as an aetiological factor for FGIDs, it also provides a review of recent evidence regarding the role of other peripheral mechanisms (the intraluminal milieu), as also genetic factors in the pathophysiology of these disorders. The article has been divided into five independent sections. The first three sections summarize the evidence of visceral hypersensitivity as a biological marker of functional gut disorders, the peripheral and central mechanisms involved, and the role of inflammation on hypersensitivity. In opposition to visceral hypersensitivity as an isolated phenomenon in functional gut disorders, the last two sections focus on the importance of peripheral mechanisms, like motor disturbances, specifically those resulting on altered transport of intestinal gas, and alterations of the intraluminal milieu and genetics.

Original languageEnglish (US)
Pages (from-to)62-88
Number of pages27
JournalNeurogastroenterology and Motility
Volume19
Issue numberSUPPL.1
DOIs
StatePublished - Jan 2007

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Hypersensitivity
Gastrointestinal Diseases
Biomarkers
Gases
Inflammation

Keywords

  • Abdominal pain
  • Functional gut disorders
  • Irritable bowel syndrome
  • Visceral hypersensitivity

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Azpiroz, F., Bouin, M., Camilleri, M., Mayer, E. A., Poitras, P., Serra, J., & Spiller, R. C. (2007). Mechanisms of hypersensitivity in IBS and functional disorders. Neurogastroenterology and Motility, 19(SUPPL.1), 62-88. https://doi.org/10.1111/j.1365-2982.2006.00875.x

Mechanisms of hypersensitivity in IBS and functional disorders. / Azpiroz, F.; Bouin, M.; Camilleri, Michael; Mayer, E. A.; Poitras, P.; Serra, J.; Spiller, R. C.

In: Neurogastroenterology and Motility, Vol. 19, No. SUPPL.1, 01.2007, p. 62-88.

Research output: Contribution to journalArticle

Azpiroz, F, Bouin, M, Camilleri, M, Mayer, EA, Poitras, P, Serra, J & Spiller, RC 2007, 'Mechanisms of hypersensitivity in IBS and functional disorders', Neurogastroenterology and Motility, vol. 19, no. SUPPL.1, pp. 62-88. https://doi.org/10.1111/j.1365-2982.2006.00875.x
Azpiroz, F. ; Bouin, M. ; Camilleri, Michael ; Mayer, E. A. ; Poitras, P. ; Serra, J. ; Spiller, R. C. / Mechanisms of hypersensitivity in IBS and functional disorders. In: Neurogastroenterology and Motility. 2007 ; Vol. 19, No. SUPPL.1. pp. 62-88.
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